INT100620

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.47
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM)
cytoplasm (VIM)
Anatomy Link Frequency
macrophages 2
stromal cells 1
neurons 1
temporomandibular joint 1
VIM (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 7 99.60 Very High Very High Very High
cytokine 5 99.42 Very High Very High Very High
rheumatoid arthritis 72 99.36 Very High Very High Very High
Inflammation 10 99.24 Very High Very High Very High
Snapping jaw 6 97.84 Very High Very High Very High
Pain 6 94.92 High High
Infliximab 24 83.76 Quite High
cINOD 3 66.64 Quite High
imagery 2 63.84 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 5 99.38 Very High Very High Very High
Rheumatoid Arthritis 72 99.36 Very High Very High Very High
INFLAMMATION 11 99.24 Very High Very High Very High
Cancer 102 98.04 Very High Very High Very High
Temporomandibular Joint Syndrome 6 97.84 Very High Very High Very High
Necrosis 4 97.80 Very High Very High Very High
Autoimmune Disease 10 97.76 Very High Very High Very High
Cleidocranial Dysplasia 1 97.52 Very High Very High Very High
Malignant Neoplastic Disease 20 97.48 Very High Very High Very High
Pain 5 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, whereas the anti-inflammatory cytokine interleukin-10 will inhibit vimentin secretion from macrophages, the pro-inflammatory cytokine tumor necrosis factor will trigger secretion (31).
Localization (secretion) of vimentin in macrophages associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.76 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.07 Pain Relevance 0.25
Interestingly, it has been recently demonstrated that vimentin is secreted by macrophages in response to pro-inflammatory signaling pathways (31).
Localization (secreted) of vimentin in macrophages associated with inflammation
2) Confidence 0.76 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.98 Pain Relevance 0.22
Immunolocalization of vimentin and alpha-smooth muscle actin in dysfunctional human temporomandibular joint disc samples.
Localization (Immunolocalization) of vimentin in temporomandibular joint associated with snapping jaw
3) Confidence 0.75 Published 2002 Journal J Oral Rehabil Section Title Doc Link 11896846 Disease Relevance 0.57 Pain Relevance 0.51
For example osteosarcoma exhibit strong positivity for Vimentin, variable for Actin/Desmin and S-100, if chondroid differentiation is present.
Localization (variable) of Vimentin associated with osteogenic sarcomas
4) Confidence 0.73 Published 2007 Journal Cytojournal Section Body Doc Link PMC1872031 Disease Relevance 0.38 Pain Relevance 0.06
Co-localization of COX-2-positive stromal cells was seen with CD68, alpha-smooth muscle actin (alpha-SMA), vimentin, and HLA-DR, but an as yet unidentified subpopulation of stromal cells remained.
Localization (Co-localization) of vimentin in stromal cells
5) Confidence 0.36 Published 2002 Journal J. Pathol. Section Abstract Doc Link 11793368 Disease Relevance 0.72 Pain Relevance 0.13
Cell cultures were tested at 1–1.5 weeks post-confluency for the presence of cytokeratins, vimentin, connexin43, desmoplakins 1&2, E-cadherin, and ZO-1.
Localization (presence) of vimentin
6) Confidence 0.36 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
Similar findings were obtained when the neurons were grouped according to their estimated locations in Voa/Vop and Vim of motor thalamus.
Localization (locations) of Vim in neurons associated with thalamus
7) Confidence 0.32 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15703231 Disease Relevance 1.05 Pain Relevance 0.57
Citrullinated vimentin is present in synovial membranes and is released in increased amounts in response to growth factors and proinflammatory cytokines, suggesting involvement in the pathophysiology of RA [24].
Localization (released) of vimentin associated with rheumatoid arthritis and cytokine
8) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656247 Disease Relevance 0.70 Pain Relevance 0.42

General Comments

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