INT100621

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.86
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
macrophages 1
Plasma 1
monocyte 1
stromal cells 1
Lym-1 1
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 170 98.80 Very High Very High Very High
Pain 18 93.76 High High
anesthesia 3 91.64 High High
Catecholamine 10 82.72 Quite High
epidural 1 79.36 Quite High
Inflammation 64 75.76 Quite High
cINOD 2 66.64 Quite High
cytokine 31 63.08 Quite High
Enkephalin 1 59.84 Quite High
depression 1 53.12 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 224 98.80 Very High Very High Very High
Cleidocranial Dysplasia 1 97.52 Very High Very High Very High
Reprotox - General 3 23 96.40 Very High Very High Very High
Lymphatic System Cancer 6 95.44 Very High Very High Very High
Pain 19 93.76 High High
Metaplasia 2 90.00 High High
Stomach Cancer 2 84.60 Quite High
Carcinoma 1 83.16 Quite High
Cancer 7 79.40 Quite High
INFLAMMATION 62 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma concentrations of epinephrine, norepinephrine, cortisol, IL-6 and IL-10 as well as monocyte surface expression of HLA-DR and their ex vivo capacity to release TNF-alpha after LPS stimulation were measured perioperatively.
Localization (capacity) of HLA-DR in Plasma
1) Confidence 0.40 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.34 Pain Relevance 0.51
Created as radionuclide targeting molecules, these SHALs were intended to have the human leukocyte antigen-DR (HLA-DR) selectivity of Lym-1 mAb and the pharmacokinetics of a small molecule.
Localization (selectivity) of HLA-DR in Lym-1
2) Confidence 0.30 Published 2006 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 17257080 Disease Relevance 0.27 Pain Relevance 0.06
Fig. 3A shows distribution of HLA-DR MDC (dark field visible light) and Fig. 3B also demonstrates CD8 T cells (dark field fluorescence).
Localization (distribution) of HLA-DR in T cells
3) Confidence 0.22 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0 Pain Relevance 0
Interestingly, although lamina propria of ectocervix showed the presence of primitive (CD14) moderately (HLA-DR) and well differentiated MDC (CD68), the monocyte-derived cells entering epithelium appear to initiate a new differentiation associated with CD1a expression and HLA-DR and CD68 secretion.


Localization (secretion) of HLA-DR in monocyte
4) Confidence 0.20 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.06 Pain Relevance 0
Co-localization of COX-2-positive stromal cells was seen with CD68, alpha-smooth muscle actin (alpha-SMA), vimentin, and HLA-DR, but an as yet unidentified subpopulation of stromal cells remained.
Localization (Co-localization) of HLA-DR in stromal cells
5) Confidence 0.14 Published 2002 Journal J. Pathol. Section Abstract Doc Link 11793368 Disease Relevance 0.72 Pain Relevance 0.13
On the other hand, emerging evidence addresses the decrease in human leukocyte antigen (HLA)-ABC and HLA-DR on peritoneal macrophages in endometriosis patients (Fig. 1), suggesting defective antigen presentation [42].
Localization (decrease) of HLA-DR in peritoneal macrophages associated with endometriosis
6) Confidence 0.06 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.13 Pain Relevance 0.40
, Zymed Lab., San Francisco, USA) to detect macrophages and (4) antihuman HLA-DR (monoclonal mouse IgG1?
Localization (monoclonal) of HLA-DR in macrophages
7) Confidence 0.05 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 0.34 Pain Relevance 0.10

General Comments

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