INT100622

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Context Info
Confidence 0.73
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 6.58
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD68) plasma membrane (CD68)
Anatomy Link Frequency
macrophages 4
epithelial cells 2
monocyte 1
stromal cells 1
CD68 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 316 99.28 Very High Very High Very High
Inflammation 60 97.44 Very High Very High Very High
cytokine 43 96.92 Very High Very High Very High
Substantia nigra 49 94.56 High High
metalloproteinase 7 91.52 High High
Spinal cord 7 88.32 High High
Arthritis 156 88.00 High High
medulla 4 85.00 Quite High
midbrain 8 84.16 Quite High
Hippocampus 2 72.32 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 65 99.34 Very High Very High Very High
Rheumatoid Arthritis 394 99.28 Very High Very High Very High
Aging 34 98.64 Very High Very High Very High
Infection 134 98.44 Very High Very High Very High
Hyperplasia 5 98.06 Very High Very High Very High
Cleidocranial Dysplasia 2 97.52 Very High Very High Very High
INFLAMMATION 59 97.44 Very High Very High Very High
Cancer 33 96.20 Very High Very High Very High
Necrosis 9 95.92 Very High Very High Very High
Cyst 11 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antigens tested by immunohistochemistry were: pan-keratin, keratin Cam 5.2, cytokeratin 7, cytokeratin 10, cytokeratin 18, cytokeratin 20, epithelial membrane antigen, vimentin, desmin, actin, myosin, CD34, CD68, CD99, CD117, S-100 protein, and bcl-2.
Localization (desmin) of CD68
1) Confidence 0.73 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2039817 Disease Relevance 0.45 Pain Relevance 0
Co-localization with the macrophage marker CD68 was only observed in a minority of COX-2-positive cells.
Localization (Co-localization) of CD68 in macrophage
2) Confidence 0.67 Published 2002 Journal J. Pathol. Section Abstract Doc Link 11793368 Disease Relevance 0.67 Pain Relevance 0.12
Lining layer hyperplasia appeared to be more pronounced in RA, both by altered apoptosis of lining cells as by increased presence of CD68+ macrophage-like synoviocytes, although macrophage-derived pro-inflammatory cytokines such as tumour necrosis factor-?
Localization (presence) of CD68 in macrophage associated with necrosis, inflammation, cancer, rheumatoid arthritis, apoptosis, hyperplasia and cytokine
3) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.83 Pain Relevance 0.76
Due to the intracellular vesicular localization of the CD68 receptor, it was not possible to directly assess the morphology of the cell expressing it by means of its staining pattern (Figure 5B).
Localization (localization) of CD68 receptor
4) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808388 Disease Relevance 0.09 Pain Relevance 0.12
Mature DC (black arrowheads) secreted CD68 among intermediate epithelial cells, and CD68 mucin-like molecules accompanied aging of epithelial cells (white arrowheads) including surface layers.
Localization (secreted) of CD68 in epithelial cells associated with aging
5) Confidence 0.52 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.10 Pain Relevance 0
Mature DC (black arrowheads) secreted CD68 among intermediate epithelial cells, and CD68 mucin-like molecules accompanied aging of epithelial cells (white arrowheads) including surface layers.
Localization (secreted) of CD68 in epithelial cells associated with aging
6) Confidence 0.52 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.10 Pain Relevance 0
To identify the cellular location of SIV and SHIV proteins, antibodies used for phenotyping in the immunohistochemical analysis [anti-CD68, anti DC-SIGN, anti-??
Localization (location) of CD68
7) Confidence 0.49 Published 2007 Journal Retrovirology Section Body Doc Link PMC1805449 Disease Relevance 0.08 Pain Relevance 0
Co-localization of positively stained CD68+ cells with p24 in this organ was indicative of infection of cells of the myeloid lineage in mature and immature animals (Fig. 5ii, panels D-F).
Localization (localization) of CD68 associated with infection
8) Confidence 0.46 Published 2007 Journal Retrovirology Section Body Doc Link PMC1805449 Disease Relevance 0.50 Pain Relevance 0
Interestingly, although lamina propria of ectocervix showed the presence of primitive (CD14) moderately (HLA-DR) and well differentiated MDC (CD68), the monocyte-derived cells entering epithelium appear to initiate a new differentiation associated with CD1a expression and HLA-DR and CD68 secretion.


Localization (secretion) of CD68 in monocyte
9) Confidence 0.45 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.06 Pain Relevance 0
Mature DC secreted CD68 and exhibited fragmentation after reaching mid intermediate layers.
Localization (secreted) of CD68
10) Confidence 0.45 Published 2001 Journal BMC Dev Biol Section Abstract Doc Link PMC34117 Disease Relevance 0 Pain Relevance 0
Mononuclear CD68-positive cells resembled macrophages and were localized either at the bone surface, or deeper within the subchondral bone space.
Localization (localized) of CD68 in macrophages
11) Confidence 0.45 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.68 Pain Relevance 0.03
While some macrophages can express CD123, there was no colocalization in synovial tissue of CD123 and CD68 (data not shown).
Localization (tissue) of CD68 in macrophages
12) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.39 Pain Relevance 0.19
CCR9 co-localised with CD14 (Figure 2a-c) and CD68 (Figure 2d-f) in RA and non-RA synovia.
Localization (localised) of CD68 associated with rheumatoid arthritis
13) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.94 Pain Relevance 0.50
For co-localisation of syndecan-3 and CD68, sections were incubated with anti-syndecan-3 (5 ?
Localization (localisation) of CD68
14) Confidence 0.31 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0 Pain Relevance 0
Co-localization of COX-2-positive stromal cells was seen with CD68, alpha-smooth muscle actin (alpha-SMA), vimentin, and HLA-DR, but an as yet unidentified subpopulation of stromal cells remained.
Localization (Co-localization) of CD68 in stromal cells
15) Confidence 0.28 Published 2002 Journal J. Pathol. Section Abstract Doc Link 11793368 Disease Relevance 0.71 Pain Relevance 0.13
Standard immunocytochemical methods, including antigen retrieval where appropriate, were used to demonstrate localization of ubiquitin, p62/sequestosome 1, TDP43, CD68 (a marker of microglial activation), ?
Localization (localization) of CD68
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0 Pain Relevance 0.36

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