INT100626

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Context Info
Confidence 0.51
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.94
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHAT) mitochondrion (CHAT) nucleus (CHAT)
transferase activity, transferring acyl groups (CHAT) cytoplasm (CHAT)
Anatomy Link Frequency
lymphocytes 1
interneurons 1
CHAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 88.80 High High
Enkephalin 34 84.72 Quite High
Inflammation 31 83.48 Quite High
agonist 27 79.12 Quite High
Neuropeptide 2 77.12 Quite High
cytokine 4 22.40 Low Low
projection neuron 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
interneuron 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 9 98.40 Very High Very High Very High
Disease 17 89.84 High High
Asthma 39 86.96 High High
Pulmonary Disease 51 86.00 High High
INFLAMMATION 36 83.48 Quite High
Ganglion Cysts 2 75.00 Quite High
Hyperplasia 5 73.44 Quite High
Eczema 1 66.88 Quite High
Pain 2 46.44 Quite Low
Hypertrophy 6 14.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presumed local production of acetylcholine (ACh), as evidenced by immunoreactivity for ChAT and VAChT and the detection of ChAT mRNA, appears to evolve in response to tendinosis.
Transcription (detection) of ChAT associated with tendinopathy
1) Confidence 0.51 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.74 Pain Relevance 0.09
Compartmental distribution of ChAT-ir interneurons in the various striatal territories of the CN and Put
Transcription (distribution) of ChAT in interneurons
2) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.24
Mononuclear leukocytes, consisting mainly of lymphocytes, express ChAT mRNA and protein, contain ACh and express muscarinic and nicotinic receptors.
Transcription (express) of ChAT in lymphocytes
3) Confidence 0.17 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 1.05 Pain Relevance 0.21
Cell bodies immunopositive for ChAT or Met-ENK were also detected and were TH-negative or TH-positive.
Transcription (detected) of ChAT
4) Confidence 0.07 Published 2002 Journal Synapse Section Abstract Doc Link 11793421 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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