INT10065

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 1.48
Pain Relevance 8.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Serpina6) extracellular space (Serpina6) extracellular region (Serpina6)
molecular_function (Serpina6) cellular_component (Serpina6) biological_process (Serpina6)
Anatomy Link Frequency
blood 5
Serpina6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 28 100.00 Very High Very High Very High
Morphine 110 99.98 Very High Very High Very High
anesthesia 4 87.64 High High
tolerance 1 84.20 Quite High
Endogenous opioid 4 76.92 Quite High
headache 1 71.64 Quite High
Disease Link Frequency Relevance Heat
Stress 14 95.20 Very High Very High Very High
Disorder Of Lipid Metabolism 1 87.00 High High
Impaired Glucose Tolerance 1 84.20 Quite High
Body Weight 1 78.28 Quite High
Hemorrhage 1 73.36 Quite High
Vomiting 1 71.96 Quite High
Headache 1 71.64 Quite High
Reprotox - General 1 2 63.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that chronic exposure of male rats to morphine markedly increases the concentration of corticosteroid-binding globulin (CBG) in blood.
Positive_regulation (increases) of CBG in blood associated with corticosteroid and morphine
1) Confidence 0.70 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694945 Disease Relevance 0 Pain Relevance 0.44
Testosterone is required for corticosteroid-binding globulin upregulation by morphine to be fully manifested.
Positive_regulation (upregulation) of corticosteroid-binding globulin associated with corticosteroid and morphine
2) Confidence 0.70 Published 2000 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11113500 Disease Relevance 0 Pain Relevance 0.79
We previously reported that morphine increases the concentration of corticosteroid-binding globulin (CBG) in blood of male, but not female, rats.
Positive_regulation (increases) of CBG in blood associated with corticosteroid and morphine
3) Confidence 0.70 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11113500 Disease Relevance 0 Pain Relevance 0.48
We previously reported that morphine increases the concentration of corticosteroid-binding globulin (CBG) in blood of male, but not female, rats.
Positive_regulation (increases) of corticosteroid-binding globulin in blood associated with corticosteroid and morphine
4) Confidence 0.70 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11113500 Disease Relevance 0 Pain Relevance 0.48
Chronic exposure to morphine increases corticosteroid-binding globulin.
Positive_regulation (increases) of corticosteroid-binding globulin associated with corticosteroid and morphine
5) Confidence 0.70 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9316834 Disease Relevance 0.06 Pain Relevance 0.62
CBG levels remained elevated while morphine was detectable in blood and returned toward normal as the drug cleared from the system.
Positive_regulation (elevated) of CBG in blood associated with morphine
6) Confidence 0.70 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.08 Pain Relevance 0.74
However, due to the elevated level of CBG, the amount of free, physiologically active hormone was dramatically reduced.
Positive_regulation (elevated) of CBG
7) Confidence 0.70 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.10 Pain Relevance 0.81
We previously reported that chronic exposure of male rats to morphine markedly increases the concentration of corticosteroid-binding globulin (CBG) in blood.
Positive_regulation (increases) of corticosteroid-binding globulin in blood associated with corticosteroid and morphine
8) Confidence 0.50 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694945 Disease Relevance 0 Pain Relevance 0.44
A single morphine pellet was sufficient to induce a marked increase in the concentration of CBG and two or more pellets caused maximal upregulation.
Positive_regulation (increase) of CBG associated with morphine
9) Confidence 0.50 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.09 Pain Relevance 0.81
This pronounced sexual dimorphism suggested that CBG upregulation by morphine might be androgen-dependent.
Positive_regulation (upregulation) of CBG associated with morphine
10) Confidence 0.47 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11113500 Disease Relevance 0 Pain Relevance 0.61
Ice bathing and cold exposure did not influence CBG, and water deprivation elevated serum CBG.
Positive_regulation (elevated) of CBG
11) Confidence 0.44 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.21 Pain Relevance 0.24
In females, ether, swimming, swimming after fasting, fasting, and fasting during cold exposure resulted in a decrease in circulating CBG.
Positive_regulation (circulating) of CBG
12) Confidence 0.44 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.20 Pain Relevance 0.22
Furthermore, the increase in CBG resulting from chronic exposure to morphine might contribute to the perpetuation of drug use and to adverse effects of drug exposure by impairing normal functions of corticosterone.
Positive_regulation (increase) of CBG associated with morphine
13) Confidence 0.41 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.08 Pain Relevance 0.76
We found that morphine caused a marked naltrexone-preventable increase (approximately 160%) in CBG in adult male rats.
Positive_regulation (increase) of CBG associated with morphine
14) Confidence 0.41 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.07 Pain Relevance 0.66
Serum binding protein (SHBG, CBG, caeruloplasmin) concentrations increased and serum androgen levels decreased.
Positive_regulation (increased) of CBG
15) Confidence 0.01 Published 1992 Journal Contraception Section Abstract Doc Link 1458894 Disease Relevance 0.59 Pain Relevance 0.11

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