INT100653

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 8.26
Pain Relevance 8.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
sciatic nerve 2
brainstem 2
DRGs 2
dorsal horn 2
Gfra1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuralgia 11 100.00 Very High Very High Very High
spinal dorsal horn 4 99.86 Very High Very High Very High
intrathecal 3 99.84 Very High Very High Very High
Neuropathic pain 49 99.64 Very High Very High Very High
Somatostatin 12 99.24 Very High Very High Very High
Analgesic 6 99.10 Very High Very High Very High
electroacupuncture 27 98.68 Very High Very High Very High
Thermal hyperalgesia 8 98.16 Very High Very High Very High
Sciatic nerve 7 97.56 Very High Very High Very High
analgesia 15 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 21 100.00 Very High Very High Very High
Neuropathic Pain 49 99.64 Very High Very High Very High
Hyperalgesia 19 98.16 Very High Very High Very High
Injury 15 97.02 Very High Very High Very High
Nociception 7 91.08 High High
Substance Withdrawal Syndrome 1 65.32 Quite High
Urological Neuroanatomy 2 59.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expressions of both GDNF and GDNFR-alpha in the frontal cortex were decreased by treatment with MK801 (0.5 mg/kg), and the expressions of GDNF in both the stem and cortex, and GDNFR-beta in the brainstem decreased by treatment with the methyl-scopolamine (0.5 mg/kg).
Negative_regulation (decreased) of Gene_expression (expressions) of GDNFR-alpha in brainstem
1) Confidence 0.58 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.13 Pain Relevance 0
Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide aggravates thermal hyperalgesia in a rat model of neuropathic pain.
Negative_regulation (Down) of Gene_expression (expression) of GFRalpha-1 associated with neuralgia, thermal hyperalgesia and neuropathic pain
2) Confidence 0.46 Published 2006 Journal Neuropharmacology Section Title Doc Link 16289634 Disease Relevance 1.22 Pain Relevance 1.06
The results showed that: (1) cumulative EA had potent analgesic effect on neuropathic pain in rats; (2) the expression of GFRalpha-1 in DRGs was down-regulated by intrathecal delivery of antisense ODN, but not by normal saline (NS) or mismatch ODN; (3) EA analgesia was significantly attenuated by antisense ODN treatment.
Negative_regulation (down-regulated) of Gene_expression (expression) of GFRalpha-1 in DRGs associated with ganglion cysts, analgesic, neuropathic pain, electroacupuncture, analgesia and intrathecal
3) Confidence 0.41 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16464682 Disease Relevance 0.98 Pain Relevance 1.73
Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide attenuates electroacupuncture analgesia on heat hyperalgesia in a rat model of neuropathic pain.
Negative_regulation (Down-regulation) of Gene_expression (expression) of GFRalpha-1 associated with neuralgia, hyperalgesia, neuropathic pain, electroacupuncture and analgesia
4) Confidence 0.41 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 16464682 Disease Relevance 0.95 Pain Relevance 1.42
In order to investigate whether GDNF signaling system was involved in EA analgesia on neuropathic pain, which was induced by chronic constriction injury (CCI) of the sciatic nerve in rats, antisense oligodeoxynucleotide (ODN) specifically against GFRalpha-1 was used in the present study to result in down-regulation of GFRalpha-1 expression.
Negative_regulation (down-regulation) of Gene_expression (expression) of GFRalpha-1 in sciatic nerve associated with eae, injury, neuropathic pain, sciatic nerve, electroacupuncture and analgesia
5) Confidence 0.41 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16464682 Disease Relevance 1.02 Pain Relevance 1.70
Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide aggravates thermal hyperalgesia in a rat model of neuropathic pain.
Negative_regulation (regulation) of Gene_expression (expression) of GFRalpha-1 associated with neuralgia, thermal hyperalgesia and neuropathic pain
6) Confidence 0.34 Published 2006 Journal Neuropharmacology Section Title Doc Link 16289634 Disease Relevance 1.22 Pain Relevance 1.06
In addition, we found a down-regulation of somatostatin (SOM) in DRG and spinal dorsal horn after expression of GFRalpha-1 was knocked down, which suggested the possible relationship between the anti-hyperalgesic effect of GDNF and GFRalpha-1 on neuropathic pain and endogenous SOM.
Negative_regulation (knocked) of Gene_expression (expression) of GFRalpha-1 in dorsal horn associated with ganglion cysts, hyperalgesia, spinal dorsal horn, neuropathic pain and somatostatin
7) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.41 Pain Relevance 1.05
In order to address the role of GDNF and GFRalpha-1 in neuropathic pain, antisense oligodeoxynucleotide (ODN) specifically against GFRalpha-1 was intrathecally administered to result in down-regulation of GFRalpha-1 expression.
Negative_regulation (down-regulation) of Gene_expression (expression) of GFRalpha-1 associated with neuropathic pain
8) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.33 Pain Relevance 0.94

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