INT100655

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2001
Last Reported 2011
Negated 5
Speculated 3
Reported most in Body
Documents 51
Total Number 54
Disease Relevance 21.49
Pain Relevance 13.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 13
nerve 6
CSF 2
blood 2
neuronal 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 167 100.00 Very High Very High Very High
cytokine 64 100.00 Very High Very High Very High
chemokine 24 100.00 Very High Very High Very High
bDMF 21 100.00 Very High Very High Very High
Inflammatory mediators 6 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
antidepressant 309 99.98 Very High Very High Very High
antagonist 28 99.98 Very High Very High Very High
diabetic neuropathy 4 99.80 Very High Very High Very High
Hippocampus 85 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 81 100.00 Very High Very High Very High
Diabetic Neuropathy 4 99.80 Very High Very High Very High
Stress 520 99.76 Very High Very High Very High
Disease 282 99.68 Very High Very High Very High
Anxiety Disorder 40 99.54 Very High Very High Very High
Neuroblastoma 59 99.08 Very High Very High Very High
Headache Disorders 6 99.00 Very High Very High Very High
Hydrocephalus 4 98.96 Very High Very High Very High
Rheumatoid Arthritis 8 98.64 Very High Very High Very High
Nociception 35 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mutual regulation of neurotrophin and GFL signalling pathways in the differentiation of non-peptidergic nociceptors marks an important step forwards in deciphering the hierarchical organization of regulatory pathways during the extrinsic control of neuronal differentiation (for a review, see Ibanez and Ernfors 2007).
Regulation (regulation) of neurotrophin in neuronal associated with nociceptor
1) Confidence 0.60 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.36
In conclusion, this detailed characterization of the human BDNF gene locus opens up insights into the mechanisms governing BDNF gene regulation in human.


Regulation (regulation) of BDNF
2) Confidence 0.55 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.04
DISCUSSION: We did not detect any difference between patients with neuropathic versus nociceptive pain and nonpainful controls for spinal CNTF, BDNF, and NGF levels.
Neg (not) Regulation (controls) of BDNF in spinal
3) Confidence 0.52 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.22 Pain Relevance 0
This article reassesses the literature concerning brain-derived neurotrophic factor expression in the sciatic nerve chronic constriction injury model, the sciatic nerve transection model, the spinal nerve ligation model and the spinal nerve transection model and discusses differences in regulation of brain-derived neurotrophic factor between these models and their causality with neuropathic pain.
Regulation (regulation) of brain-derived neurotrophic factor in spinal nerve associated with eae, injury, neuropathic pain and sciatic nerve
4) Confidence 0.52 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19959385 Disease Relevance 0.49 Pain Relevance 0.67
For changes in gene expression or brain-derived neurotrophic factor (BDNF) levels, however, the most reliable data are for pre- to post-treatment changes, and the question of how early in treatment changes that might be predictive of outcome could be detected remains unclear.
Regulation (changes) of brain-derived neurotrophic factor in brain
5) Confidence 0.48 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2965366 Disease Relevance 0.21 Pain Relevance 0.07
For changes in gene expression or brain-derived neurotrophic factor (BDNF) levels, however, the most reliable data are for pre- to post-treatment changes, and the question of how early in treatment changes that might be predictive of outcome could be detected remains unclear.
Regulation (changes) of BDNF in brain
6) Confidence 0.48 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2965366 Disease Relevance 0.21 Pain Relevance 0.07
Here, we provide the first evidence that fishes possess a simplified proteolytic regulation of BDNF and that the pro28KDa proteolytic product, whose function remains yet to be determined, is absent at this stage of vertebrates evolution.
Regulation (regulation) of BDNF
7) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.22 Pain Relevance 0
These results suggest that the level of brain-derived neurotrophic factor protein in visual cortex is regulated by activities of cortical neurons.
Regulation (regulated) of brain-derived neurotrophic factor protein in brain
8) Confidence 0.48 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614676 Disease Relevance 0 Pain Relevance 0.29
A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy.
Regulation (placebo-controlled) of brain-derived neurotrophic factor in brain associated with diabetic neuropathy
9) Confidence 0.45 Published 2001 Journal J. Peripher. Nerv. Syst. Section Title Doc Link 11800042 Disease Relevance 0.28 Pain Relevance 0.05
At baseline, neurotrophin concentrations did not differ significantly between the investigated skin sites.
Neg (not) Spec (investigated) Regulation (differ) of neurotrophin in skin
10) Confidence 0.44 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18571954 Disease Relevance 0.36 Pain Relevance 0.58
The underlying molecular mechanisms are at present unknown; however, recent evidence from several groups suggest that different signaling mechanisms may be responsible for the regulation of BDNF transcription [2].
Regulation (regulation) of BDNF
11) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.16 Pain Relevance 0.24
A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy.
Regulation (placebo-controlled) of rhBDNF in brain associated with diabetic neuropathy
12) Confidence 0.39 Published 2001 Journal J. Peripher. Nerv. Syst. Section Title Doc Link 11800042 Disease Relevance 0.28 Pain Relevance 0.05
A randomized, double-blind, placebo-controlled study of brain-derived neurotrophic factor (rhBDNF) was conducted in 30 patients with insulin-treated diabetes mellitus, with obligatory abnormalities of sural nerve conduction studies and vibration perception threshold (VPT) at the great toe on recruitment.
Regulation (placebo-controlled) of rhBDNF in nerve associated with congenital anomalies and diabetes mellitus
13) Confidence 0.39 Published 2001 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 11800042 Disease Relevance 0.27 Pain Relevance 0.04
In order to verify our conclusion regarding the expression level of BDNF in the AD patients in our dataset, we examined the expression level of BDNF in the controls and AD affected samples.
Spec (examined) Regulation (verify) of BDNF associated with disease and bdmf
14) Confidence 0.39 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.47
MMPs have many other properties, including the ability to modulate cytokines and growth factors (such as TNF-alpha and BDNF among others) by processing their proforms into active forms [22].
Regulation (modulate) of BDNF associated with metalloproteinase and cytokine
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820097 Disease Relevance 0.88 Pain Relevance 0.49
However, different and sometimes conflicting findings have been reported [2], showing that antidepressants change total BDNF expression level depending on length of the treatment and time interval following administration.
Regulation (change) of BDNF associated with antidepressant
16) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.33 Pain Relevance 0.23
Recent rodent studies reported that antidepressant treatments affect the expression of brain-derived neurotrophic factor (BDNF) mRNA in a way that is dependent on treatment duration, by selective modulation of different BDNF transcripts.
Regulation (modulation) of BDNF in brain associated with antidepressant
17) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2483719 Disease Relevance 0.16 Pain Relevance 0.32
The increasing knowledge of BDNF gene in rodents [7,8] has encouraged the research on the modulation of different BDNF transcripts by pharmacological treatments.
Regulation (modulation) of BDNF
18) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.31 Pain Relevance 0.24
These changes were accounted for by differential regulation of BDNF IV and VIa/b transcripts.
Regulation (regulation) of BDNF IV
19) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2483719 Disease Relevance 0.15 Pain Relevance 0.50
Interestingly, previous studies in rodents have shown a differential regulation of distinct BDNF transcripts by antidepressant treatments [6,9,11].
Regulation (regulation) of BDNF associated with antidepressant
20) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.18 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox