INT100661

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 5.93
Pain Relevance 7.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cst7)
Anatomy Link Frequency
nerve 4
muscle 2
Cst7 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 1454 100.00 Very High Very High Very High
ischemia 52 100.00 Very High Very High Very High
Demyelination 3 99.28 Very High Very High Very High
carpal tunnel syndrome 117 99.20 Very High Very High Very High
c fibre 39 94.44 High High
backache 1 91.04 High High
Sciatic nerve 54 86.88 High High
Pain 4 83.68 Quite High
peripheral neuropathy 2 47.28 Quite Low
Sciatica 3 45.44 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 66 100.00 Very High Very High Very High
Injury 163 99.68 Very High Very High Very High
Demyelinating Disease 3 99.28 Very High Very High Very High
Carpal Tunnel Syndrome 135 99.20 Very High Very High Very High
Stroke 10 99.12 Very High Very High Very High
Sepsis 57 98.96 Very High Very High Very High
Neuropathic Pain 14 97.38 Very High Very High Very High
Motor Neuron Diseases 9 96.94 Very High Very High Very High
Nervous System Injury 54 95.32 Very High Very High Very High
Low Back Pain 1 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goal of this paper was to study the changes in the compound muscle action potential (CMAP) during acute mechanical compression.
Regulation (changes) of CMAP in muscle associated with action potential
1) Confidence 0.53 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2245939 Disease Relevance 0.18 Pain Relevance 0.26
It demonstrated that a pure compression injury produced large changes in CMAP amplitude prior to large changes in conduction velocity.
Regulation (changes) of CMAP associated with action potential and injury
2) Confidence 0.39 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2245939 Disease Relevance 0.41 Pain Relevance 0.29
In studies that aimed to investigate the effects of ischemia on nerve action potential [16], CMAP [17], and evoked potential [18], it was found that 50% reduction in CMAP amplitude was sufficient to elicit a 20% reduction in nerve conduction velocity, which is again larger than seen in this study.
Spec (investigate) Regulation (effects) of CMAP in nerve associated with action potential and ischemia
3) Confidence 0.39 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.40 Pain Relevance 0.68
Although, in this study, correlations of changes in multiple variables including the mean CMAP latency and the CMAP latency variance did not help detect statistically significant changes at an earlier point, they would be useful in confirming the presence of significant changes.
Regulation (changes) of CMAP associated with action potential
4) Confidence 0.39 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.25 Pain Relevance 0.38
Figure 3C demonstrates that the CMAP onset and mean latency, do not change significantly during the early phases of compression.
Neg (not) Regulation (change) of CMAP associated with action potential
5) Confidence 0.39 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.27
Although, in this study, correlations of changes in multiple variables including the mean CMAP latency and the CMAP latency variance did not help detect statistically significant changes at an earlier point, they would be useful in confirming the presence of significant changes.
Regulation (changes) of CMAP associated with action potential
6) Confidence 0.39 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.25 Pain Relevance 0.39
The Comprehensive Muscular Activity Profile (CMAP): its high sensitivity, specificity and overall classification rate for detecting submaximal effort on functional capacity testing.
Regulation (sensitivity) of CMAP
7) Confidence 0.34 Published 2009 Journal J Occup Rehabil Section Title Doc Link 19011955 Disease Relevance 0.26 Pain Relevance 0.17
Unlike other neuropathic conditions such as ALS, where the neuropathy is known to be degenerative in nature, nerve compression injuries can cause both demyelination and axonal loss, both of which can affect the shape characteristics of a CMAP, making it difficult to determine which pathology is most prevalent.
Regulation (affect) of CMAP in nerve associated with action potential, demyelination, injury, neuropathic pain and motor neuron diseases
8) Confidence 0.30 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2928769 Disease Relevance 1.13 Pain Relevance 0.75
RESULTS: Although no statistically significant difference of the recovery of MDL and the amplitude of CMAP and SNAP was detected between the two groups at any time point during follow-up, one patient in the ECTR group in whom the operation had been converted to OCTR, showed delay of MDL and decrease in the amplitude of CMAP.
Neg (no) Regulation (difference) of CMAP
9) Confidence 0.27 Published 2002 Journal Clin Neurophysiol Section Body Doc Link 11801426 Disease Relevance 0.18 Pain Relevance 0
However, in the clinical arena, with the many problems involved in obtaining high quality recordings, it important and critical to correlate the changes in multiple variables simultaneously in order to confirm the presence and nature of significant changes in the CMAP.
Regulation (changes) of CMAP associated with action potential
10) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.20 Pain Relevance 0.33
It should be noted that the changes in CMAP amplitude and velocity in this model are very different than those observed during ischemia or nerve stretch [15].
Regulation (changes) of CMAP in nerve associated with action potential and ischemia
11) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.25 Pain Relevance 0.70
The ability to detect statistically significant changes in the CMAP at low force levels using other descriptors of the CMAP including duration, latency variation, etc alone or in conjunction with amplitude and velocity measures was investigated.
Regulation (changes) of CMAP associated with action potential
12) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2245939 Disease Relevance 0.35 Pain Relevance 0.37
In order to better elucidate the changes in the CMAP, figures 4 and 5 show the normalized CMAP velocity and CMAP duration respectively from each recorded potential as a function of the normalized CMAP amplitude.
Regulation (changes) of CMAP associated with action potential
13) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.43
One caveat to the use of continuous CMAP recording is that, although the CMAP is high in amplitude and thus easy to monitor, changes in the CMAP can be more difficult to interpret than changes the in the nerve action potential.
Regulation (changes) of CMAP in nerve associated with action potential
14) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0.18 Pain Relevance 0.44
Four other features of the CMAP are computed, the duration, the area under the curve (AUC), the mean value of the CMAP latency and its variance.
Regulation (value) of CMAP associated with action potential
15) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.49
However, none of these derived parameters showed statistically significant changes in the CMAP at an earlier point than either the CMAP amplitude or velocity alone.
Regulation (changes) of CMAP associated with action potential
16) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245939 Disease Relevance 0 Pain Relevance 0.40
Integral values of CMAP were also decreased in CTS patients.
Regulation (values) of CMAP associated with action potential and carpal tunnel syndrome
17) Confidence 0.23 Published 2002 Journal J Orthop Surg (Hong Kong) Section Abstract Doc Link 12401924 Disease Relevance 0.68 Pain Relevance 0.99
Hemiparetic side mean values of the compound muscle action potential (CMAP) 1 and 3 weeks after stroke were compared with the nonparetic side and with CMAP values obtained from healthy control subjects.
Regulation (values) of CMAP in muscle associated with action potential and stroke
18) Confidence 0.21 Published 2007 Journal J Clin Neurophysiol Section Abstract Doc Link 18090526 Disease Relevance 0.73 Pain Relevance 0.26
Our results indicate no change in CMAP duration but a decrease in amplitude and observable prolongation of the latency which is regarded as an indicator of axonal degeneration.
Neg (no) Regulation (change) of CMAP associated with action potential
19) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151871 Disease Relevance 0.49 Pain Relevance 0.22

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