INT100672

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.84
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
regulatory T cells 2
Th2 cells 1
T cell 1
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 248 100.00 Very High Very High Very High
Inflammation 224 98.44 Very High Very High Very High
antagonist 35 92.64 High High
Enkephalin 1 71.36 Quite High
chemokine 30 66.96 Quite High
withdrawal 2 65.28 Quite High
Inflammatory response 18 64.88 Quite High
tolerance 3 62.16 Quite High
aspirin 1 60.80 Quite High
fibrosis 6 43.60 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 244 98.44 Very High Very High Very High
Bites And Stings 5 97.60 Very High Very High Very High
Myocardial Infarction 23 97.20 Very High Very High Very High
Autoimmune Disease 9 95.20 Very High Very High Very High
Disease 81 94.40 High High
Francisella Infection 29 94.16 High High
Infection 147 93.36 High High
Asthma 321 92.16 High High
Targeted Disruption 52 88.44 High High
Convalescence 9 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The description of the Th2/Th1 balance may explain parts of an immune response, however the immune regulation is more complex, involving other cytokines, cell surface molecules and regulatory T cells.
Transcription (description) of Th2 in regulatory T cells associated with cytokine
1) Confidence 0.42 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.30 Pain Relevance 0.23
Regulatory T cells overexpress a subset of Th2 gene transcripts.
Transcription (transcripts) of Th2 in Regulatory T cells
2) Confidence 0.41 Published 2002 Journal J. Immunol. Section Title Doc Link 11801640 Disease Relevance 0.10 Pain Relevance 0.10
Lower relative expression of cardiomyogenic transcription factors, such as GATA-4, Nkx2-5, Isl-1, Mef2 and Hand2, was seen in clonal cell culture.
Transcription (transcription) of Hand2
3) Confidence 0.34 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.36 Pain Relevance 0
ligands (troglitazone, pioglitazone, and rosiglitazone) increases the expression of the specific Th2 transcription factor, GATA-3.
Transcription (transcription) of Th2
4) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.20
was observed [11], [16], [21], [24], it was preceded by a strong and early induction of Th2 transcripts, such as IL-4, IL-5 and IL-13.
Transcription (transcripts) of Th2
5) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.72 Pain Relevance 0.13
Notably, expression of mRNA encoding the Th2 signature cytokine IL-4 was up-regulated 2791-fold at tick bite sites (P < 0.001) and 527-fold at intradermal injection sites (P < 0.001) of 10 ?
Transcription (expression) of Th2 associated with bites and stings and cytokine
6) Confidence 0.26 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.31 Pain Relevance 0.18
In this study, we have identified twist1 as a gene that is differentially expressed by Th1 cells versus Th2 cells, comparing the transcriptomes of once and repeatedly restimulated murine Th1 and Th2 cells generated in vitro from bona fide naive Th cells.
Transcription (transcriptomes) of Th2 in Th2 cells
7) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.18 Pain Relevance 0.09
Furthermore, aminophylline decreases Th2-related cytokine mRNA expression but increases Th1-related cytokines mRNA expression [35].


Transcription (expression) of Th2-related associated with cytokine
8) Confidence 0.12 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.66 Pain Relevance 0.37
The sequential events include induction of CD 80/86 on the B cell that engages CD28 on the T cell, leading to transcription of pivotal Th2 cytokines IL-4 and/or IL-13.
Transcription (transcription) of Th2 in T cell associated with cytokine
9) Confidence 0.07 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.16

General Comments

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