INT100678

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.63
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (STAT6) signal transducer activity (STAT6) cytosol (STAT6)
extracellular space (IL4) signal transduction (STAT6) extracellular region (IL4)
IL4 (Homo sapiens)
STAT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 4 99.68 Very High Very High Very High
aspirin 24 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 16 99.92 Very High Very High Very High
Disease 16 99.56 Very High Very High Very High
Asthma 12 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that treatment of cell lines and primary cells with aspirin and salicylates, but not acetaminophen, inhibited the activation of STAT6 by IL-4 and IL-13.
IL-4 Positive_regulation (activation) of STAT6 associated with aspirin and paracetamol
1) Confidence 0.49 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801685 Disease Relevance 0.64 Pain Relevance 0.27
Because STAT6 activation by IL-4 and IL-13 participates in the development of allergic diseases, our results provide a mechanism to explain the beneficial effects of aspirin and salicylate treatment of these diseases.
IL-4 Positive_regulation (activation) of STAT6 associated with aspirin, hypersensitivity and disease
2) Confidence 0.49 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801685 Disease Relevance 0.57 Pain Relevance 0.24
Although salicylates inhibited the in vivo activation of Janus kinases, their kinase activity was not affected in vitro by salicylates, suggesting that other kinases were involved in IL-4-induced STAT6 activation.
IL-4 Positive_regulation (activation) of STAT6
3) Confidence 0.33 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801685 Disease Relevance 0.68 Pain Relevance 0.27
Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6.
IL-4 Positive_regulation (activation) of STAT6 associated with aspirin
4) Confidence 0.33 Published 2002 Journal J. Immunol. Section Title Doc Link 11801685 Disease Relevance 0.74 Pain Relevance 0.30

General Comments

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