INT100688

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 15.51
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
Anatomy Link Frequency
Cardiomyocytes 1
lung 1
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 5 99.52 Very High Very High Very High
mu opioid receptor 15 98.52 Very High Very High Very High
Enkephalin 1 96.28 Very High Very High Very High
headache 3 93.04 High High
Immobilon 9 92.64 High High
Migraine 5 91.88 High High
Root ganglion neuron 1 87.00 High High
cytokine 25 86.68 High High
Pain 48 86.40 High High
opiate 27 79.68 Quite High
Disease Link Frequency Relevance Heat
Cancer 519 99.92 Very High Very High Very High
Pancreatic Cancer 397 99.92 Very High Very High Very High
Prostate Cancer 53 99.84 Very High Very High Very High
Malignant Neoplastic Disease 12 99.32 Very High Very High Very High
Mesothelioma 47 99.28 Very High Very High Very High
Adhesions 47 99.04 Very High Very High Very High
Lung Cancer 21 99.04 Very High Very High Very High
Ovarian Cancer 136 98.52 Very High Very High Very High
Adenocarcinoma 16 98.52 Very High Very High Very High
Disease Progression 3 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High cytoplasmic c-Src expression (Allred score 7-8) was seen in 33/47 (70%) tumors.
Gene_expression (expression) of c-Src associated with cancer
1) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.88 Pain Relevance 0.06
Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma.
Gene_expression (Coexpression) of c-Src associated with adenocarcinoma
2) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Title Doc Link 14627343 Disease Relevance 0.62 Pain Relevance 0
We then sought to link c-Src and STAT3 in our 3D model through the adenoviral expression of a dominant negative form of c-Src (DNSrc).
Gene_expression (expression) of c-Src
3) Confidence 0.75 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
In this study we assessed the activation status of five oncogenic signaling pathways in 157 ovarian tumor samples based on the activation observed in a mammalian cell line following tranfection of adenovirus expressing human c-Myc, activated H-Ras, human c-Src, human E2F3, or ?
Gene_expression (expressing) of c-Src associated with ovarian cancer
4) Confidence 0.75 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.47 Pain Relevance 0
In this study we assessed the activation status of five oncogenic signaling pathways in 157 ovarian tumor samples based on the activation observed in a mammalian cell line following tranfection of adenovirus expressing human c-Myc, activated H-Ras, human c-Src, human E2F3, or ?
Gene_expression (human) of c-Src associated with ovarian cancer
5) Confidence 0.65 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.46 Pain Relevance 0
PyV is capable of transforming cells by triggering signal transduction pathways that have been implicated as activated by erbB2, through interactions between its mT gene product and key cellular signaling proteins such as c-Src [14,15], Shc, and phosphatidylinositol 3-kinase (PI3-K) [16], which have all been implicated as important in human breast cancer.
Gene_expression (product) of c-Src associated with breast cancer
6) Confidence 0.65 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.27 Pain Relevance 0
In cells transfected with dominant-negative c-Src and TRPV1, capsaicin-induced currents were decreased by approximately fourfold.
Gene_expression (transfected) of c-Src associated with qutenza
7) Confidence 0.65 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15084474 Disease Relevance 0.09 Pain Relevance 0.40
Detection limits of 2 microM were obtained for pp60 c-src (P) and M2170.
Gene_expression (obtained) of c-src
8) Confidence 0.65 Published 2003 Journal Anal. Chem. Section Abstract Doc Link 14670045 Disease Relevance 0 Pain Relevance 0.10
In support of this, other recent studies37, 38 also demonstrate integrin-mediated c-Src activation and FAC formation can contribute to STAT3 phosphorylation/activation.
Gene_expression (activation) of c-Src
9) Confidence 0.65 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
Generation of c-Src Adenoviral Constructs and their Expression in Adult Cardiomyocytes
Gene_expression (Generation) of c-Src in Cardiomyocytes
10) Confidence 0.58 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.06 Pain Relevance 0
Furthermore, we found that an Src kinase was involved in STAT6 activation because 1) Src kinase activity was induced by IL-4, 2) Src kinase activity, but not Janus kinase, was inhibited by salicylates in vitro, 3) cells expressing viral Src had constitutive STAT6 phosphorylation, and 4) cells lacking Src showed low STAT6 phosphorylation in response to IL-4.
Gene_expression (expressing) of Src
11) Confidence 0.55 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801685 Disease Relevance 0.63 Pain Relevance 0.25
Several studies of bevacizumab in combination with pemetrexed and platinum are ongoing.Src is very frequently expressed and activated in mesothelioma.
Gene_expression (expressed) of Src associated with mesothelioma
12) Confidence 0.47 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 0.33 Pain Relevance 0
Transfection of siRNA against mTOR, Src, Rictor, FKBP12 and Akt
Gene_expression (Transfection) of Src
13) Confidence 0.46 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.05
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
Gene_expression (activation) of Src associated with mu opioid receptor
14) Confidence 0.46 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.34 Pain Relevance 0.55
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
Gene_expression (kinase) of Src-regulated associated with mu opioid receptor
15) Confidence 0.46 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.34 Pain Relevance 0.54
C-Src is frequently overexpressed and/or aberrantly activated in a variety of epithelial and non-epithelial cancers including colorectal, breast cancers, melanomas, ovarian cancer, lung cancer and pancreatic cancer.
Gene_expression (overexpressed) of C-Src in lung associated with lung cancer, melanoma, cancer, pancreatic cancer, ovarian cancer and breast cancer
16) Confidence 0.39 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.30 Pain Relevance 0.04
They consist of eight families with the major ones including SRC, JAK, ABL, FAK (Levitzki 1999).


Gene_expression (ones) of SRC
17) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.34 Pain Relevance 0
, Ras/MAPK, Src kinase and Jak/Stat kinase pathways.
Gene_expression (kinase) of Src
18) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.49 Pain Relevance 0
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Gene_expression (expression) of C-Src associated with pancreatic cancer
19) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Gene_expression (over) of C-Src associated with pancreatic cancer
20) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04

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