INT10069

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lhb) molecular_function (Lhb) cellular_component (Lhb)
biological_process (Lhb)
Anatomy Link Frequency
DA neurons 1
follicle 1
striatum 1
boutons 1
Lhb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 21 100.00 Very High Very High Very High
gABA 6 99.32 Very High Very High Very High
antagonist 3 99.12 Very High Very High Very High
Nucleus accumbens 21 98.72 Very High Very High Very High
midbrain 42 95.16 Very High Very High Very High
Eae 6 85.56 High High
GABAergic 15 80.84 Quite High
Limbic system 6 74.64 Quite High
IPN 129 74.16 Quite High
monoamine 21 49.64 Quite Low
Disease Link Frequency Relevance Heat
Handedness 42 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 27 5.00 Very Low Very Low Very Low
Schizophrenia 21 5.00 Very Low Very Low Very Low
Cognitive Disorder 21 5.00 Very Low Very Low Very Low
Depression 21 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Psychosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppressing LHb activity with a GABA antagonist causes increases in DA release in the Acb and striatum of similar timecourse and magnitude to those observed during reward-seeking behaviour (but causes a significantly smaller increase in the prefrontal cortex).
Negative_regulation (Suppressing) of LHb in striatum associated with gaba and antagonist
1) Confidence 0.49 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0 Pain Relevance 0.50
A subset of MHb axons project through the LHb and in so doing display en passant boutons that might represent presynaptic terminals (Kim & Chang 2005), and sectioning of the MHb efferent axons has been reported to reduce substance P levels in the LHb (see Sutherland 1982).


Negative_regulation (reduce) of LHb in boutons associated with substance p
2) Confidence 0.36 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0 Pain Relevance 0.48
The LHb is one of the few regions of the brain to be inhibited by hedonic stimuli (Gallistel et al. 1985), and recently, Matsumoto & Hikosaka (2007) have shown that the LHb instructs midbrain DA neurons as to the absence of a reward.
Negative_regulation (inhibited) of LHb in DA neurons associated with midbrain
3) Confidence 0.36 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0 Pain Relevance 0.38
Northern blot analysis was used to measure AP prodynorphin, luteinizing hormone-beta (LH beta), follicle-stimulating hormone-beta (FSH beta), and common alpha-subunit mRNA levels (normalized to 18S ribosomal RNA).
Negative_regulation (measure) of luteinizing hormone-beta in follicle
4) Confidence 0.23 Published 1992 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 1459342 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox