INT100694

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.27
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
blood 4
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 99.66 Very High Very High Very High
mu opioid receptor 1 96.68 Very High Very High Very High
Cannabinoid 8 94.96 High High
antagonist 2 94.20 High High
cytokine 31 93.68 High High
rheumatoid arthritis 54 91.52 High High
opioid receptor 9 87.56 High High
Cannabinoid receptor 2 85.24 High High
agonist 1 75.00 Quite High
Paracetamol 1 73.24 Quite High
Disease Link Frequency Relevance Heat
Infection 68 100.00 Very High Very High Very High
Hypersensitivity 8 99.56 Very High Very High Very High
Disease 72 99.20 Very High Very High Very High
Cancer 3 98.84 Very High Very High Very High
Asthma 27 98.40 Very High Very High Very High
Recurrence 4 92.64 High High
Rheumatoid Arthritis 54 91.52 High High
Eosinophilia 26 90.48 High High
Syndrome 3 66.72 Quite High
Lymphadenopathy 10 58.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With respect to the increase of IL-4, the combination was significantly additive to the effect of either IL-7 or IL-4 alone.


Negative_regulation (effect) of Positive_regulation (increase) of IL-4
1) Confidence 0.34 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.38 Pain Relevance 0.19
Induction of interleukin-4 is blocked by decoy oligonucleotides directed against STAT5, indicating the requirement of this transcription factor.
Negative_regulation (blocked) of Positive_regulation (Induction) of interleukin-4
2) Confidence 0.33 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.80
Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6.
Negative_regulation (inhibit) of Positive_regulation (activation) of IL-4 associated with aspirin
3) Confidence 0.27 Published 2002 Journal J. Immunol. Section Title Doc Link 11801685 Disease Relevance 0.74 Pain Relevance 0.30
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decreased) of Positive_regulation (levels) of IL-4 in blood
4) Confidence 0.22 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.79 Pain Relevance 0.15
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decrease) of Positive_regulation (levels) of IL-4 in blood
5) Confidence 0.22 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.81 Pain Relevance 0.15
The anti-DC-SIGN antibodies that blocked DV infection of IL-4 treated MDMØ to the greatest degree (DC28 and 120612) are known to cross react with DC-SIGNR.
Negative_regulation (blocked) of Positive_regulation (treated) of IL-4 associated with infection
6) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.54 Pain Relevance 0

General Comments

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