INT100698

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.85
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Chd7) helicase activity (Chd7) DNA binding (Chd7)
Anatomy Link Frequency
liver 1
Chd7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 98.90 Very High Very High Very High
cINOD 46 90.08 High High
aspirin 28 89.68 High High
diclofenac 8 63.28 Quite High
anesthesia 1 61.64 Quite High
Inflammatory stimuli 2 51.92 Quite High
cytokine 6 17.52 Low Low
chemokine 8 5.00 Very Low Very Low Very Low
transdermal 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 98.90 Very High Very High Very High
Stress 28 97.36 Very High Very High Very High
Toxicity 4 77.60 Quite High
Apoptosis 4 72.28 Quite High
Cv Unclassified Under Development 26 71.04 Quite High
Endometriosis (extended) 18 69.76 Quite High
Rickettsiaceae Infection 43 67.68 Quite High
Disease 22 67.16 Quite High
Infection 9 59.92 Quite High
Epidemic Louse-borne Typhus 9 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, WHI was also affected by some methodological constraints.
Regulation (affected) of WHI
1) Confidence 0.34 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.14 Pain Relevance 0
Thus, we cannot project the likely impact of our findings on the failure to detect a cardioprotective effect of HT in WHI.
Regulation (effect) of WHI
2) Confidence 0.25 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1872041 Disease Relevance 0.07 Pain Relevance 0.27
Treatment with L1, on the other hand, had no effect on liver or kidney copper and MT, but resulted in increased brain copper and MT levels.
Neg (no) Regulation (effect) of MT in liver
3) Confidence 0.07 Published 2002 Journal J. Inorg. Biochem. Section Abstract Doc Link 11803042 Disease Relevance 0.35 Pain Relevance 0.06
Metallothionein as an Anti-Inflammatory Mediator

The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes.

Regulation (regulation) of MT associated with inflammation
4) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Title Doc Link PMC2679981 Disease Relevance 0.56 Pain Relevance 0.16
under the control of the yeast MT promoter also protects against oxidative
Regulation (control) of MT promoter
5) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.48 Pain Relevance 0
4-fold increase in IFA titer between paired serum samples as the diagnostic criterion, sensitivity of the MT IBT for admission-phase samples was 61.2% (112 of 183; 95% CI = 53.7–68.3%).
Regulation (sensitivity) of MT IBT
6) Confidence 0.01 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2911186 Disease Relevance 0.25 Pain Relevance 0

General Comments

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