INT10070

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 3.48
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fshb) cytoplasm (Fshb)
Anatomy Link Frequency
follicle 9
plasma 1
pituitary 1
postovulatory follicle 1
sperm 1
Fshb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 4 99.46 Very High Very High Very High
butorphanol 6 99.08 Very High Very High Very High
Morphine 10 98.76 Very High Very High Very High
narcan 4 97.32 Very High Very High Very High
Serotonin 2 93.48 High High
ketamine 4 92.56 High High
Dismenorea 3 87.48 High High
Dysuria 1 86.48 High High
Pain 9 85.52 High High
Opioid 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 6 99.82 Very High Very High Very High
Uterine Fibroids 6 99.44 Very High Very High Very High
Cancer 5 99.16 Very High Very High Very High
Ovarian Cysts 8 98.48 Very High Very High Very High
Prostate Cancer 4 94.84 High High
Metastasis 2 93.52 High High
Depression 3 93.44 High High
Reprotox - General 1 15 87.48 High High
Pain 9 85.52 High High
Endometriosis (extended) 37 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While 4 days of M or 5 mm [corrected] T treatment were without significant effect, the combination dramatically decreased circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Negative_regulation (decreased) of follicle-stimulating hormone in follicle
1) Confidence 0.42 Published 1988 Journal Brain Res. Section Abstract Doc Link 2454704 Disease Relevance 0 Pain Relevance 0.25
LH beta mRNA was suppressed by all steroid treatments (p < 0.01), FSH beta was lower in only the E2 group, and alpha-subunit was reduced in both the E2 + P4 and DHT groups (p < 0.01).
Negative_regulation (lower) of FSH beta
2) Confidence 0.38 Published 1992 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 1459342 Disease Relevance 0 Pain Relevance 0
Northern blot analysis was used to measure AP prodynorphin, luteinizing hormone-beta (LH beta), follicle-stimulating hormone-beta (FSH beta), and common alpha-subunit mRNA levels (normalized to 18S ribosomal RNA).
Negative_regulation (measure) of FSH beta in follicle
3) Confidence 0.38 Published 1992 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 1459342 Disease Relevance 0 Pain Relevance 0
Northern blot analysis was used to measure AP prodynorphin, luteinizing hormone-beta (LH beta), follicle-stimulating hormone-beta (FSH beta), and common alpha-subunit mRNA levels (normalized to 18S ribosomal RNA).
Negative_regulation (measure) of follicle-stimulating hormone-beta in follicle
4) Confidence 0.38 Published 1992 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 1459342 Disease Relevance 0 Pain Relevance 0
Both morphine and butorphanol, at the 2 doses used, produced more than 76% decrease in serum follicle stimulating hormone concentration.
Negative_regulation (decrease) of follicle stimulating hormone in follicle associated with butorphanol and morphine
5) Confidence 0.33 Published 1991 Journal Arch Exp Veterinarmed Section Abstract Doc Link 1789717 Disease Relevance 0.17 Pain Relevance 1.12
Studies were undertaken to analyze the role of endogenous opioids in chronic stress-induced decrease in circulating LH and follicle-stimulating hormone (FSH).
Negative_regulation (decrease) of follicle-stimulating hormone in follicle associated with stress and endogenous opioid
6) Confidence 0.26 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1749459 Disease Relevance 0.26 Pain Relevance 0.27
Norplant achieves its contraceptive effect by inhibiting the positive feedback exercised by estradiol on the hypothalamus and thus reducing levels of luteinizing hormone and follicle stimulating hormone, by rendering the cervical mucus inhospitable to passage of sperm, and by altering the composition of the endometrial tissue.
Negative_regulation (reducing) of follicle stimulating hormone in sperm
7) Confidence 0.10 Published 1992 Journal Profamilia Section Abstract Doc Link 12286384 Disease Relevance 0.41 Pain Relevance 0.13
With hormone therapy the basal follicle-stimulating hormone and luteinizing hormone levels decreased significantly while basal plasma estrone and estradiol increased significantly.
Negative_regulation (decreased) of follicle-stimulating hormone in plasma
8) Confidence 0.09 Published 1986 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3024488 Disease Relevance 0 Pain Relevance 0.24
The drug combination caused a measurable suppression of follicle stimulating hormone levels in both castrated does and during the postovulatory follicle stimulating hormone surge in mated rabbits.
Negative_regulation (suppression) of follicle stimulating hormone in postovulatory follicle
9) Confidence 0.08 Published 1982 Journal Lab. Anim. Sci. Section Abstract Doc Link 6819406 Disease Relevance 0 Pain Relevance 0.23
A tendency toward decreases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and low-density lipoprotein cholesterol (LDL-C) at all doses and decreases in N-telopeptide of type I collagen (NTx) at the higher doses (0.3 and 1.0 mg/day) was reported.
Negative_regulation (decreases) of follicle-stimulating hormone in follicle
10) Confidence 0.06 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 0.26 Pain Relevance 0
A tendency toward decreases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and low-density lipoprotein cholesterol (LDL-C) at all doses and decreases in N-telopeptide of type I collagen (NTx) at the higher doses (0.3 and 1.0 mg/day) was reported.
Negative_regulation (decreases) of follicle-stimulating hormone in follicle
11) Confidence 0.06 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 0.26 Pain Relevance 0
Afterwards, continuous treatment using analogs produced a long-term reduction in leiomyomas (less than 60%) along with decreases in the serum levels of luteinizing hormone, follicle-stimulating hormone, estradiol, and the tumor marker CA-125, and adverse effects including slight boneloss.
Negative_regulation (decreases) of follicle-stimulating hormone in follicle associated with uterine fibroids and cancer
12) Confidence 0.06 Published 1998 Journal In Vivo Section Abstract Doc Link 9706480 Disease Relevance 0.71 Pain Relevance 0.09
Leuprorelin acetate depot suppressed serum luteinizing hormone, follicle stimulating hormone and testosterone concentrations.
Negative_regulation (suppressed) of follicle stimulating hormone in follicle
13) Confidence 0.04 Published 1990 Journal J. Int. Med. Res. Section Abstract Doc Link 2108889 Disease Relevance 0.62 Pain Relevance 0.17
OCs are known to suppress follicle stimulating hormone and luteinizing hormone, the pituitary gonadotrophins.
Negative_regulation (suppress) of follicle stimulating hormone in pituitary
14) Confidence 0.02 Published 1982 Journal Contracept Technol Update Section Abstract Doc Link 12338303 Disease Relevance 0.80 Pain Relevance 0

General Comments

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