INT100720

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA2D2) plasma membrane (CACNA2D2)
CACNA2D2 (Homo sapiens)
Pain Link Frequency Relevance Heat
pregabalin 11 100.00 Very High Very High Very High
Gabapentin 7 100.00 Very High Very High Very High
Eae 4 99.50 Very High Very High Very High
Neuropathic pain 3 94.32 High High
noradrenaline 1 93.04 High High
Potency 1 89.20 High High
Dorsal horn 3 88.16 High High
antagonist 1 81.20 Quite High
dorsal root ganglion 3 78.40 Quite High
Calcium channel 1 60.48 Quite High
Disease Link Frequency Relevance Heat
Injury 4 99.50 Very High Very High Very High
Neuropathic Pain 3 94.32 High High
Ganglion Cysts 3 77.44 Quite High
Nervous System Injury 1 35.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have investigated the anatomical binding profile of [(3)H] pregabalin following chronic constriction injury (CCI) and compared this with alpha 2 delta 1 subunit expression using in situ hybridisation.
Gene_expression (expression) of alpha 2 delta 1 subunit associated with pregabalin, eae and injury
1) Confidence 0.46 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17367933 Disease Relevance 0.68 Pain Relevance 0.89
The alpha 2 delta-1, alpha 2 delta-2, and alpha 2 delta-3 subunits of voltage-gated Ca(2+) channels, presumed sites of gabapentin and pregabalin action, were detected with immunoblots of human neocortical synaptosomes.
Gene_expression (detected) of alpha 2 delta-2 associated with pregabalin and gabapentin
2) Confidence 0.27 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11804619 Disease Relevance 0 Pain Relevance 1.19

General Comments

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