INT100726

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Context Info
Confidence 0.27
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, F2RL1) signal transduction (TNF) extracellular space (TNF)
extracellular region (TNF) Golgi apparatus (F2RL1) intracellular (TNF)
Anatomy Link Frequency
bowel 2
TNF (Homo sapiens)
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 98.00 Very High Very High Very High
agonist 12 80.80 Quite High
tetrodotoxin 1 79.40 Quite High
chemokine 18 72.24 Quite High
fibrosis 4 71.84 Quite High
Glutamate 48 7.68 Low Low
antagonist 28 5.00 Very Low Very Low Very Low
nMDA receptor 24 5.00 Very Low Very Low Very Low
Opioid 14 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
INFLAMMATION 7 98.00 Very High Very High Very High
Inflammatory Bowel Disease 1 96.44 Very High Very High Very High
Toxicity 82 91.84 High High
Death 48 84.12 Quite High
Apoptosis 42 83.72 Quite High
Cystic Fibrosis 4 71.84 Quite High
Viral Meningitis 4 59.36 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 178 58.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAR-2-mediated intestinal electrolyte secretion by release of mast cell tryptase and potentiation of PAR-2 expression by tumor necrosis factor-alpha may contribute to the hypersecretion observed in inflammatory processes such as chronic inflammatory bowel disease.
tumor necrosis factor-alpha Positive_regulation (potentiation) of Gene_expression (expression) of PAR-2 in bowel associated with necrosis, inflammation and cancer
1) Confidence 0.27 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11804840 Disease Relevance 0.65 Pain Relevance 0.31
In addition to increased prostaglandin formation, TNF-alpha increases the expression of proteinase-activated receptor-2 (PAR-2) which is responsible for cell survival [34].
TNF-alpha Positive_regulation (increases) of Gene_expression (expression) of PAR-2
2) Confidence 0.01 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.62 Pain Relevance 0.08
In addition to increased prostaglandin formation, TNF-alpha increases the expression of proteinase-activated receptor-2 (PAR-2) which is responsible for cell survival [34].
TNF-alpha Positive_regulation (increases) of Gene_expression (expression) of proteinase-activated receptor-2
3) Confidence 0.01 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.62 Pain Relevance 0.08

General Comments

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