INT100729

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2009
Negated 0
Speculated 3
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 5.29
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
tooth pulp 2
nerves 2
cartilage 1
colon 1
fibroblast 1
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 12 100.00 Very High Very High Very High
qutenza 2 99.14 Very High Very High Very High
vanilloid receptor subtype 1 2 98.74 Very High Very High Very High
Bioavailability 2 98.48 Very High Very High Very High
Osteoarthritis 132 98.24 Very High Very High Very High
Pain 19 95.76 Very High Very High Very High
Inflammation 146 93.96 High High
fibrosis 12 87.00 High High
Neuropeptide 10 86.48 High High
tetrodotoxin 3 82.80 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 134 98.24 Very High Very High Very High
Cancer 15 97.04 Very High Very High Very High
Necrosis 13 96.80 Very High Very High Very High
Pain 19 95.76 Very High Very High Very High
Dyspepsia 48 95.36 Very High Very High Very High
INFLAMMATION 129 93.96 High High
Inflammatory Bowel Disease 5 92.40 High High
Cystic Fibrosis 12 87.28 High High
Pressure And Volume Under Development 2 78.16 Quite High
Gastroesophageal Reflux Disease 90 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIMS: To investigate the presence of proteinase-activated receptor 2 (PAR2) in the human tooth pulp and to determine whether there are any changes in receptor expression with caries and pain.
Spec (investigate) Localization (presence) of proteinase-activated receptor 2 in tooth pulp associated with pain
1) Confidence 0.75 Published 2009 Journal J Orofac Pain Section Abstract Doc Link 19639106 Disease Relevance 0.17 Pain Relevance 0.17
AIMS: To investigate the presence of proteinase-activated receptor 2 (PAR2) in the human tooth pulp and to determine whether there are any changes in receptor expression with caries and pain.
Spec (investigate) Localization (presence) of PAR2 in tooth pulp associated with pain
2) Confidence 0.75 Published 2009 Journal J Orofac Pain Section Abstract Doc Link 19639106 Disease Relevance 0.17 Pain Relevance 0.17
The coronal pulp was removed and processed for indirect immunofluorescence by using antibodies raised against PAR2 and double labeled with either a neuronal marker (protein gene product 9.5) or both a smooth muscle cell (aSMA) and endothelial (UEIL) marker, in order to examine PAR2 presence in both neuronal and vascular tissue.
Spec (examine) Localization (presence) of PAR2 in neuronal
3) Confidence 0.75 Published 2009 Journal J Orofac Pain Section Body Doc Link 19639106 Disease Relevance 0.08 Pain Relevance 0
Our finding of an increased level of PAR-2 induced by TGF-?
Localization (level) of PAR-2
4) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.67 Pain Relevance 0.39
Figure 1c illustrates that PAR-2 is localized mainly in the superficial zone (consisting of the superficial and upper intermediate layers) in normal and OA cartilage.


Localization (localized) of PAR-2 in cartilage associated with osteoarthritis
5) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.51 Pain Relevance 0.33
Proteinase-activated receptor (PAR) type 2 (PAR-2) has been shown to mediate ion secretion in cultured epithelial cells and rat jejunum.
Localization (secretion) of PAR-2 in jejunum
6) Confidence 0.68 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11804840 Disease Relevance 0.28 Pain Relevance 0.14
PAR-2-mediated intestinal electrolyte secretion by release of mast cell tryptase and potentiation of PAR-2 expression by tumor necrosis factor-alpha may contribute to the hypersecretion observed in inflammatory processes such as chronic inflammatory bowel disease.
Localization (secretion) of PAR-2-mediated in bowel associated with necrosis, inflammation and cancer
7) Confidence 0.64 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11804840 Disease Relevance 0.65 Pain Relevance 0.31
Activation of ion secretion via proteinase-activated receptor-2 in human colon.
Localization (secretion) of proteinase-activated receptor-2 in colon
8) Confidence 0.56 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11804840 Disease Relevance 0.32 Pain Relevance 0.23
As a result, the mucosal levels of transient receptor potential vanilloid receptor subtype 1 (TRPV1: a capsaicin-, heat-, and acid-sensitive ion channel), protease-activated receptor 2 (PAR2: a receptor for trypsin), substance P, which is secreted by TRPV1- and PAR2-positive nerves, and the NK1 receptor (a receptor for substance P) were significantly higher in NERD patients than in normal subjects [5].
Localization (secreted) of PAR2 in nerves associated with vanilloid receptor subtype 1, qutenza, dyspepsia and substance p
9) Confidence 0.18 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.06 Pain Relevance 0.76
As a result, the mucosal levels of transient receptor potential vanilloid receptor subtype 1 (TRPV1: a capsaicin-, heat-, and acid-sensitive ion channel), protease-activated receptor 2 (PAR2: a receptor for trypsin), substance P, which is secreted by TRPV1- and PAR2-positive nerves, and the NK1 receptor (a receptor for substance P) were significantly higher in NERD patients than in normal subjects [5].
Localization (secreted) of protease-activated receptor 2 in nerves associated with vanilloid receptor subtype 1, qutenza, dyspepsia and substance p
10) Confidence 0.18 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.12 Pain Relevance 0.77
In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively.
Localization (release) of H2O2-activated in fibroblast
11) Confidence 0.01 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.27 Pain Relevance 0.10

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