INT100732

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 55
Total Number 70
Disease Relevance 38.89
Pain Relevance 19.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
cartilage 6
chondrocytes 4
epithelial cells 4
tooth pulp 3
fibroblasts 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 535 100.00 Very High Very High Very High
Hyperalgesia 98 99.92 Very High Very High Very High
Osteoarthritis 1761 99.84 Very High Very High Very High
qutenza 30 99.74 Very High Very High Very High
bradykinin 6 99.42 Very High Very High Very High
Inflammation 1012 99.40 Very High Very High Very High
Chronic pancreatitis 8 99.32 Very High Very High Very High
Nerve growth factor 23 99.08 Very High Very High Very High
cytokine 378 99.06 Very High Very High Very High
fibrosis 72 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 246 100.00 Very High Very High Very High
Hyperalgesia 129 99.92 Very High Very High Very High
Pancreatic Cancer 48 99.88 Very High Very High Very High
Osteoarthritis 1743 99.84 Very High Very High Very High
Cancer 422 99.84 Very High Very High Very High
Malignant Neoplastic Disease 22 99.84 Very High Very High Very High
Cough 27 99.80 Very High Very High Very High
Necrosis 91 99.60 Very High Very High Very High
INFLAMMATION 1085 99.40 Very High Very High Very High
Pancreatitis 8 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No changes in vascular PAR2 expression were found (P > .05); however, the number of PAR2-labeled fibroblast-like cells per mm2 was significantly greater in carious teeth (P < .05).
Gene_expression (expression) of PAR2 in teeth
1) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19639106 Disease Relevance 0.06 Pain Relevance 0
Changes in proteinase-activated receptor 2 expression in the human tooth pulp in relation to caries and pain.
Gene_expression (expression) of proteinase-activated receptor 2 in tooth pulp associated with pain
2) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Title Doc Link 19639106 Disease Relevance 0.10 Pain Relevance 0.19
RESULTS: PAR2 expression was found to be present in pulpal nerve fibers, vascular tissue, and pulpal fibroblasts.
Gene_expression (expression) of PAR2 in fibroblasts
3) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19639106 Disease Relevance 0.07 Pain Relevance 0
PAR2 neuronal expression was not affected by the presence of caries (P > .05) but was significantly less in carious painful teeth than in carious asymptomatic teeth (P < .05).
Gene_expression (expression) of PAR2 in teeth
4) Confidence 0.78 Published 2009 Journal J Orofac Pain Section Body Doc Link 19639106 Disease Relevance 0.06 Pain Relevance 0
Expression of proteinase-activated receptor-2 in human pancreatic cancer: a possible relation to cancer invasion and induction of fibrosis.
Gene_expression (Expression) of proteinase-activated receptor-2 associated with fibrosis, cancer and pancreatic cancer
5) Confidence 0.78 Published 2003 Journal Int. J. Oncol. Section Title Doc Link 12527925 Disease Relevance 1.05 Pain Relevance 0.21
Moreover, significantly higher expression of PAR-2 was observed in the tissues which were accompanied by severe fibrosis.
Gene_expression (expression) of PAR-2 associated with fibrosis
6) Confidence 0.78 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 1.22 Pain Relevance 0.35
And to evaluate the biological significance, immunohistochemical expression of PAR-2 in malignant and non-malignant human pancreatic tissues was examined using paraffin-embedded sections.
Spec (examined) Gene_expression (expression) of PAR-2 associated with malignant neoplastic disease
7) Confidence 0.78 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 0.89 Pain Relevance 0.09
Similarly, the higher expression of PAR-2 was observed in chronic pancreatitis with severe fibrosis than with mild fibrosis.
Gene_expression (expression) of PAR-2 associated with fibrosis and chronic pancreatitis
8) Confidence 0.78 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 1.25 Pain Relevance 0.42
To clarify the presence of PAR-2 in human pancreatic cancer, the expression of PAR-2 was analyzed by RT-PCR, immunoblotting and immunocytochemistry using 5 human pancreatic cancer cell lines.
Spec (analyzed) Gene_expression (expression) of PAR-2 associated with pancreatic cancer
9) Confidence 0.78 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 0.73 Pain Relevance 0.04
The expression of PAR-2 was found to be higher in the tissues with infiltrative growth pattern than those with expansive growth pattern.
Gene_expression (expression) of PAR-2
10) Confidence 0.78 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 1.18 Pain Relevance 0.28
Data (n = 3 to 4) revealed that only the p38 inhibitor markedly downregulated (p < 0.06) the PAR-2 production in OA cartilage (Figure 3).
Gene_expression (production) of PAR-2 in cartilage associated with osteoarthritis
11) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.82 Pain Relevance 0.55
PAR-2 is produced by human chondrocytes and is significantly upregulated in OA compared with normal chondrocytes (p < 0.04 and p < 0.03, respectively).
Gene_expression (produced) of PAR-2 in chondrocytes associated with osteoarthritis
12) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.70 Pain Relevance 0.46
Here, we showed that PAR-2 expression and protein levels were significantly increased in OA compared with normal human chondrocytes and that the levels are upregulated by the proinflammatory cytokines IL-1?
Gene_expression (expression) of PAR-2 in chondrocytes associated with osteoarthritis and cytokine
13) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.43 Pain Relevance 0.21
Recently, PAR-2 expression has been found in chondrocytes and synovial fibroblasts [12,13].
Gene_expression (expression) of PAR-2 in fibroblasts
14) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 1.34 Pain Relevance 0.70
B, as regulators of PAR-2 synthesis.
Gene_expression (synthesis) of PAR-2
15) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.18 Pain Relevance 0.21
Our finding that the PAR-2-AP, in addition to activating PAR-2, significantly upregulates the level of the receptor on OA chondrocytes agrees with a recent study showing that another PAR-2-AP agonist, 2-furoyl LIGKV-OH (ASK95), regulates the expression of PAR-2 in umbilical vein endothelial cells [18].
Gene_expression (expression) of PAR-2 in endothelial cells associated with agonist and osteoarthritis
16) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.28 Pain Relevance 0.26
In this study, we also addressed the roles of candidate signalling events able to regulate PAR-2 production and, on the other hand, those responsible for the PAR-2-mediated functional response.
Gene_expression (production) of PAR-2
17) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.20 Pain Relevance 0.22
PAR-2 expression was determined using real-time reverse transcription-polymerase chain reaction and protein levels by immunohistochemistry in normal and OA cartilage.
Gene_expression (expression) of PAR-2 in cartilage associated with osteoarthritis
18) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.95 Pain Relevance 0.55
To explore the signalling pathways involved in the regulation of PAR-2 synthesis, human OA cartilage explants were incubated for 48 hours with the MAP kinase inhibitor SB 202190, inhibitor of p38; PD 98059, inhibitor of MEK1/2; and SN50, inhibitor of NF-?
Gene_expression (synthesis) of PAR-2 in cartilage associated with osteoarthritis
19) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.76 Pain Relevance 0.46
PAR2 was coexpressed with TRPV1 in small- to medium-diameter neurons of the dorsal root ganglia (DRG), as determined by immunofluorescence.
Gene_expression (coexpressed) of PAR2 in neurons
20) Confidence 0.75 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.44 Pain Relevance 0.92

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