INT100733

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 62
Total Number 104
Disease Relevance 59.14
Pain Relevance 35.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
chondrocytes 7
mast cell 5
cartilage 4
bowel 3
sensory neurons 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2231 100.00 Very High Very High Very High
Osteoarthritis 1782 100.00 Very High Very High Very High
agonist 1414 100.00 Very High Very High Very High
qutenza 44 100.00 Very High Very High Very High
Inflammatory mediators 249 99.96 Very High Very High Very High
Kinase C 23 99.92 Very High Very High Very High
primary afferent fibers 3 99.84 Very High Very High Very High
antagonist 265 99.60 Very High Very High Very High
cytokine 565 99.28 Very High Very High Very High
metalloproteinase 679 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 1809 100.00 Very High Very High Very High
Disease 422 100.00 Very High Very High Very High
Pruritus 35 99.84 Very High Very High Very High
INFLAMMATION 2551 99.68 Very High Very High Very High
Eczema 15 99.52 Very High Very High Very High
Cancer 1027 99.36 Very High Very High Very High
Endometriosis 224 98.92 Very High Very High Very High
Cough 79 98.88 Very High Very High Very High
Ganglion Cysts 2 98.88 Very High Very High Very High
Injury 32 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients.
Positive_regulation (increased) of PAR-2 associated with agonist and eczema
1) Confidence 0.70 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12867500 Disease Relevance 0.89 Pain Relevance 0.32
PAR-2 was markedly enhanced on primary afferent nerve fibers in skin biopsies of AD patients.
Positive_regulation (enhanced) of PAR-2 in nerve associated with primary afferent fibers and eczema
2) Confidence 0.70 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12867500 Disease Relevance 0.93 Pain Relevance 0.36
Taken together, these results suggest that the activation of PAR-2 is involved in cancer invasion and the induction of fibrosis in human pancreatic cancer.
Positive_regulation (activation) of PAR-2 associated with fibrosis, cancer and pancreatic cancer
3) Confidence 0.70 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 1.49 Pain Relevance 0.42
This peptide activates PAR-2 independently of proteolytic unmasking of the tethered ligand sequence and triggers G-protein coupling [3].
Positive_regulation (activates) of PAR-2
4) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.37 Pain Relevance 0.30
In the OA cells as in cartilage, PAR-2-AP treatment (n = 3) also markedly increased PAR-2 protein levels (Figure 2b).
Positive_regulation (increased) of PAR-2 in cartilage associated with osteoarthritis
5) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.66 Pain Relevance 0.36
PAR-2 is produced by human chondrocytes and is significantly upregulated in OA compared with normal chondrocytes (p < 0.04 and p < 0.03, respectively).
Positive_regulation (upregulated) of PAR-2 in chondrocytes associated with osteoarthritis
6) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.71 Pain Relevance 0.47
, which strongly activate p38 in articular joints [23,24], also upregulate PAR-2.
Positive_regulation (upregulate) of PAR-2 in joints
7) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.14 Pain Relevance 0.18
Data showed that on both sets this factor markedly increased PAR-2 expression levels (20- and 42-fold, respectively; data not shown).
Positive_regulation (increased) of PAR-2
8) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.72 Pain Relevance 0.42
PAR2 activation also potentiated capsaicin-induced release of substance P and calcitonin gene-related peptide from superfused segments of the dorsal horn of the spinal cord, where they mediate hyperalgesia.
Positive_regulation (activation) of PAR2 in dorsal horn associated with hyperalgesia, qutenza, dorsal horn, spinal cord, calcitonin gene-related peptide and substance p
9) Confidence 0.67 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.41 Pain Relevance 1.66
Activation of PAR2 or PKC induced phosphorylation of TRPV1 in HEK cells, suggesting a direct regulation of the channel.
Positive_regulation (Activation) of PAR2 in HEK associated with kinase c
10) Confidence 0.67 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.55 Pain Relevance 1.55
Activation of PAR-2 during inflammation or tissue injury at the periphery is pronociceptive, while PAR-1 appears to be antinociceptive.
Positive_regulation (Activation) of PAR-2 associated with inflammation, injury and antinociceptive
11) Confidence 0.66 Published 2003 Journal Yakugaku Zasshi Section Abstract Doc Link 12875236 Disease Relevance 1.07 Pain Relevance 0.92
PAR2 activation and the cell cycle
Positive_regulation (activation) of PAR2
12) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.19 Pain Relevance 0.12
Complement genes 1r and 4a, which are particularly important for complement activation via the classical pathway, were slightly down-regulated, suggesting that PAR2 activation indirectly leads to inhibition of the classical pathway of complement activation.
Positive_regulation (activation) of PAR2
13) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.14 Pain Relevance 0.07
PAR2 activation induces PAR2 expression
Positive_regulation (activation) of PAR2
14) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.17 Pain Relevance 0.14
An unexpected effect of PAR2 activation by both trypsin and agonist peptide was seen on Mitogen-Activated Protein Kinase (MAPK) genes.
Positive_regulation (activation) of PAR2 associated with agonist
15) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.07 Pain Relevance 0.11
To identify candidate genes that might be differentially expressed as a result of PAR2 activation in human embryonic kidney cells (HEK293), cDNA microarray analyses were performed using a human Compugen array of ?
Positive_regulation (activation) of PAR2 in embryonic kidney
16) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.24 Pain Relevance 0.17
Another surprise was that PAR2 activation led to some differential expression of 5 key genes associated with complement activation (Figure 4).
Positive_regulation (activation) of PAR2
17) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.20 Pain Relevance 0.05
Mast cell tryptase seems to be an important mediator in itch by its activation of proteinase activated receptor 2 in the sensory nerves.
Positive_regulation (activation) of proteinase activated receptor 2 in Mast cell associated with pruritus
18) Confidence 0.61 Published 2003 Journal Am J Clin Dermatol Section Abstract Doc Link 12926980 Disease Relevance 1.58 Pain Relevance 0.29
Since activation of PAR2 exhibits many features similar to cytokines regarding the activation of inflammatory mediator release, this study sought to characterise the differences and similarities of the signalling pathways mediated by both PAR2 and TNF?
Positive_regulation (activation) of PAR2 associated with inflammation and cytokine
19) Confidence 0.56 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.27 Pain Relevance 0.36
Thus, we identified enhanced PAR-2 signaling as a new link between inflammatory and sensory phenomena in AD patients.
Positive_regulation (enhanced) of PAR-2 associated with inflammation and eczema
20) Confidence 0.50 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12867500 Disease Relevance 0.97 Pain Relevance 0.39

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