INT100743

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Context Info
Confidence 0.54
First Reported 2002
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 2.37
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (KCNH2) plasma membrane (KCNH2) transmembrane transport (KCNH2)
cytoplasm (KCNH2)
Anatomy Link Frequency
oocytes 2
heart 1
KCNH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 20 99.92 Very High Very High Very High
fluoxetine 14 99.56 Very High Very High Very High
addiction 15 92.52 High High
opiate 4 92.12 High High
tricyclic antidepressant 2 90.80 High High
Analgesic 2 90.52 High High
antidepressant 6 86.40 High High
Central nervous system 3 84.84 Quite High
Serotonin 2 82.76 Quite High
Mexiletine 21 77.24 Quite High
Disease Link Frequency Relevance Heat
Arrhythmogenic Right Ventricular Dysplasia 4 99.08 Very High Very High Very High
Ovarian Cancer 31 98.64 Very High Very High Very High
Arrhythmia Under Development 6 96.72 Very High Very High Very High
Syncope 7 93.96 High High
Heart Rate Under Development 5 93.44 High High
Disease 17 92.76 High High
Opiate Addiction 4 92.52 High High
Cancer 29 80.28 Quite High
Colon Cancer 2 75.96 Quite High
Leukemia 1 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the electrophysiological basis for the arrhythmogenic potential of fluoxetine, we investigated the effects of this drug on cloned human ether-a-go-go-related gene (HERG) potassium channels heterologously expressed in Xenopus oocytes using the two-microelectrode voltage-clamp technique.
Spec (investigated) Regulation (effects) of ether-a-go-go-related gene in oocytes associated with potassium channel, arrhythmogenic right ventricular dysplasia and fluoxetine
1) Confidence 0.54 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805215 Disease Relevance 0.29 Pain Relevance 0.90
To determine the electrophysiological basis for the arrhythmogenic potential of fluoxetine, we investigated the effects of this drug on cloned human ether-a-go-go-related gene (HERG) potassium channels heterologously expressed in Xenopus oocytes using the two-microelectrode voltage-clamp technique.
Spec (investigated) Regulation (effects) of HERG in oocytes associated with potassium channel, arrhythmogenic right ventricular dysplasia and fluoxetine
2) Confidence 0.45 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11805215 Disease Relevance 0.29 Pain Relevance 0.90
Droperidol affected HERG channels mainly in their open and inactivated states.
Regulation (affected) of HERG
3) Confidence 0.39 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349188 Disease Relevance 0 Pain Relevance 0
We also sought to examine a role for Eag and HERG channels in the proliferation of ovarian cancer cells.


Spec (examine) Regulation (role) of HERG associated with ovarian cancer
4) Confidence 0.38 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.04 Pain Relevance 0.03
The major active metabolite of l-alpha-acetylmethadol, noracetylmethadol, inhibited HERG with an estimated IC(50) values of 12 microM. l-alpha-acetylmethadol had little or no effect on Kv4.3 or KvLQT1/minK K(+) channel currents at concentration up to 10 microM.
Neg (no) Regulation (effect) of HERG
5) Confidence 0.36 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.16 Pain Relevance 0.30
But there was no relevant effect on HERG channel deactivation.
Neg (no) Regulation (effect) of HERG
6) Confidence 0.24 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349188 Disease Relevance 0 Pain Relevance 0
This polymorphism has been studied extensively and found to affect HERG channel function, but there is no clear consensus on whether the altered function favors QT prolongation, shortening, or a combination of the two depending on physiological conditions such as heart rate[39]–[42].
Regulation (affect) of HERG in heart
7) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.07 Pain Relevance 0.21
To understand the mechanism underlying these clinical findings, we examined the effects of l-alpha-acetylmethadol on the cloned human cardiac K(+) channels HERG (human ether-a-go-go-related gene), KvLQT1/minK and Kv4.3.
Spec (examined) Regulation (effects) of HERG
8) Confidence 0.22 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12498903 Disease Relevance 0.19 Pain Relevance 0.23
In addition, it has been shown that dynamic regulation of the Herg K+ channels may be achieved via receptor-mediated changes in phosphatidyl inositol bisphosphate (PIP2) concentrations; elevated PIP2 accelerated activation and slowed inactivation kinetics [31].
Regulation (regulation) of Herg
9) Confidence 0.09 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC117783 Disease Relevance 0.34 Pain Relevance 0.04

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