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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Folh1) plasma membrane (Folh1) nucleus (Folh1)
cytoplasm (Folh1)
Anatomy Link Frequency
plasma 1
Folh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 2 100.00 Very High Very High Very High
diabetic neuropathy 4 99.20 Very High Very High Very High
Neuropeptide 1 96.88 Very High Very High Very High
ischemia 2 95.16 Very High Very High Very High
Neuropathic pain 1 94.52 High High
Inflammation 1 87.12 High High
cINOD 2 25.00 Low Low
COX-2 inhibitor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 4 99.20 Very High Very High Very High
Cv Unclassified Under Development 2 95.16 Very High Very High Very High
Neuropathic Pain 1 94.52 High High
Diabetes Mellitus 2 93.84 High High
Neurological Disease 1 93.40 High High
INFLAMMATION 2 87.12 High High
Toxicity 1 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since ischemia is believed to be a prominent mechanism involved in diabetic polyneuropathy (DPN), we investigated the effect of the glutamate carboxypeptidase II (GCPII, EC #3.4-17.21; previously termed NAALADase), an enzyme responsible for the hydrolysis of the neuropeptide NAAG to NAA and glutamate, on the development of DPN in type 1 diabetic BB/Wor rats.
Spec (investigated) Regulation (effect) of GCPII associated with glutamate, diabetes mellitus, diabetic neuropathy and neuropeptide
1) Confidence 0.30 Published 2002 Journal J. Neurol. Sci. Section Abstract Doc Link 11809162 Disease Relevance 0.91 Pain Relevance 0.52
The present study was designed to investigate the effects of a selective cycloogenase-2 (COX-2) inhibitor, etoricoxib, on the membrane-specific enzymes, lipid composition, and changes in fluidity parameters of rat colonic plasma membrane.
Spec (investigate) Regulation (effects) of membrane-specific in plasma
2) Confidence 0.02 Published 2008 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 19105535 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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