INT100763

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2002
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.82
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpa2) extracellular region (Cpa2)
Cpa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
diabetic neuropathy 8 99.20 Very High Very High Very High
Neuropeptide 2 96.60 Very High Very High Very High
ischemia 4 95.16 Very High Very High Very High
Neuropathic pain 2 94.52 High High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 8 99.20 Very High Very High Very High
Cv Unclassified Under Development 4 95.16 Very High Very High Very High
Neuropathic Pain 2 94.52 High High
Diabetes Mellitus 4 93.56 High High
Neurological Disease 2 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since ischemia is believed to be a prominent mechanism involved in diabetic polyneuropathy (DPN), we investigated the effect of the glutamate carboxypeptidase II (GCPII, EC #3.4-17.21; previously termed NAALADase), an enzyme responsible for the hydrolysis of the neuropeptide NAAG to NAA and glutamate, on the development of DPN in type 1 diabetic BB/Wor rats.
Spec (investigated) Regulation (effect) of carboxypeptidase II associated with glutamate, diabetes mellitus, diabetic neuropathy and neuropeptide
1) Confidence 0.08 Published 2002 Journal J. Neurol. Sci. Section Abstract Doc Link 11809162 Disease Relevance 0.91 Pain Relevance 0.52
Since ischemia is believed to be a prominent mechanism involved in diabetic polyneuropathy (DPN), we investigated the effect of the glutamate carboxypeptidase II (GCPII, EC #3.4-17.21; previously termed NAALADase), an enzyme responsible for the hydrolysis of the neuropeptide NAAG to NAA and glutamate, on the development of DPN in type 1 diabetic BB/Wor rats.
Spec (investigated) Regulation (effect) of carboxypeptidase II associated with glutamate, diabetes mellitus, diabetic neuropathy and neuropeptide
2) Confidence 0.06 Published 2002 Journal J. Neurol. Sci. Section Abstract Doc Link 11809162 Disease Relevance 0.91 Pain Relevance 0.52

General Comments

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