INT100769

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
T cells 2
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 1 94.40 High High
Neuritis 2 82.80 Quite High
electroacupuncture 6 50.00 Quite Low
cytokine 5 50.00 Quite Low
lidocaine 2 50.00 Quite Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 93.24 High High
Disease 1 84.60 Quite High
Experimental Autoimmune Neuritis 2 82.80 Quite High
Adhesions 2 77.68 Quite High
Asthma 2 53.20 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by a significant reduction in mRNA levels for IFN-gamma and inducible nitric oxide synthase.
Negative_regulation (reduction) of Transcription (levels) of IFN-gamma
1) Confidence 0.42 Published 2002 Journal Acta Neuropathol. Section Abstract Doc Link 11810178 Disease Relevance 0.64 Pain Relevance 0.20
Th1 cytokine (IL-2 and interferon-gamma) production and mRNA expression in splenic T cells of traumatized rats were significantly decreased on postoperative day 3 (P < 0.001, trauma group versus control group), whereas Th2 cytokine (IL-4 and IL-10) production and mRNA expression were increased (P < 0.001).
Negative_regulation (decreased) of Transcription (expression) of interferon-gamma in T cells
2) Confidence 0.12 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
However, lidocaine inhibited, in a dose-dependent manner, the proliferative response and mRNA expression and protein production of IL-5 and IFN-gamma of PBMCs stimulated with D farinae, purified protein derivatives, or phorbol 12-myristate 13-acetate plus calcium ionophore.
Negative_regulation (inhibited) of Transcription (expression) of IFN-gamma
3) Confidence 0.02 Published 2002 Journal J. Allergy Clin. Immunol. Section Body Doc Link 11897996 Disease Relevance 0.05 Pain Relevance 0

General Comments

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