INT100772

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 3.47
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TXNRD1) small molecule metabolic process (TXNRD1) cytoplasm (TXNRD1)
cytosol (TXNRD1) signal transduction (TXNRD1) oxidoreductase activity (TXNRD1)
Anatomy Link Frequency
TrA 3
skin 1
nociceptor 1
TXNRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nociceptor 96 100.00 Very High Very High Very High
qutenza 99 99.52 Very High Very High Very High
imagery 5 99.10 Very High Very High Very High
Pain 161 98.20 Very High Very High Very High
c fibre 87 93.32 High High
tetrodotoxin 2 92.16 High High
backache 17 89.04 High High
noradrenaline 1 88.60 High High
Dopamine 1 87.88 High High
anesthesia 6 87.68 High High
Disease Link Frequency Relevance Heat
Tricuspid Valve Insufficiency 3 100.00 Very High Very High Very High
Fistula 7 98.84 Very High Very High Very High
Pain 127 98.20 Very High Very High Very High
Recurrence 1 97.64 Very High Very High Very High
Cognitive Disorder 11 93.08 High High
Low Back Pain 17 89.04 High High
Pressure Volume 2 Under Development 3 84.16 Quite High
Increased Venous Pressure Under Development 6 82.00 Quite High
Heart Rate Under Development 1 80.44 Quite High
Cv General 2 Under Development 1 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the response was variable, pain produced differential changes in the motor control of the trunk muscles, with consistent impairment of TrA activity.
Negative_regulation (impairment) of TrA in TrA associated with pain
1) Confidence 0.41 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12783146 Disease Relevance 0.46 Pain Relevance 0.60
After the repair of the aortocaval fistula, the hemodynamics became stable, RV motion was improved, TR was reduced, and CVP became normal.
Negative_regulation (reduced) of TR associated with tricuspid valve insufficiency and fistula
2) Confidence 0.38 Published 2009 Journal J Anesth Section Abstract Doc Link 19234833 Disease Relevance 1.42 Pain Relevance 0.49
Interestingly, skin sensitization did not change TR IIa (t(15) = 1, p = 0.357), but significantly attenuated the power decrease of the TR IIb (t(15) = 2.5; p = 0.024; ?
Negative_regulation (decrease) of TR IIb in skin
3) Confidence 0.30 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.06 Pain Relevance 0.44
A previous study used ultrasound imaging to show that healthy subjects automatically recruited the transversus abdominis (TrA) and internal oblique (IO) muscles in response to a simulated weight-bearing task.
Negative_regulation (recruited) of TrA in TrA associated with imagery
4) Confidence 0.26 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19015895 Disease Relevance 0.54 Pain Relevance 0.63
Recent experiments also suggest the importance of a mutual inhibitory interaction at spinal or supraspinal sites of A- and C-nociceptor activation affecting the brain activity induced by either fiber system.33,34 Enhanced C-nociceptor background activity following capsaicin sensitization may therefore have contributed to diminished A-nociceptor ER I/TR I activity.
Negative_regulation (diminished) of TR I in nociceptor associated with qutenza and nociceptor
5) Confidence 0.22 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.27 Pain Relevance 1.55
TR I) and was reduced by topical capsaicin treatment.
Negative_regulation (reduced) of TR I associated with qutenza
6) Confidence 0.22 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0.09 Pain Relevance 0.82
The more pronounced effect of intraoperative reposition (decrease of tr) with the rigid instrumentation is counteracted by marked recurrence of slip towards follow-up.
Negative_regulation (decrease) of tr associated with recurrence
7) Confidence 0.05 Published 2003 Journal German Medical Science : GMS e-journal Section Body Doc Link PMC2703223 Disease Relevance 0.10 Pain Relevance 0
Improvements in sensorimotor functions were indicated by the significant decrease in Tr area (the fast component) of postural sway and jerk index (see also below) of cervical rotation.
Negative_regulation (decrease) of Tr
8) Confidence 0.04 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2625342 Disease Relevance 0.22 Pain Relevance 0.07
These mutations include RXR A416D or R421L, which specifically disrupt the formation of the RXR/TR heterodimer, and RXR A416K, which disrupts RXR/RAR and RXR/TR [58].
Negative_regulation (disrupts) of TR
9) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
People with LBP had less TrA EMG activity with leg tasks, and there was no difference between groups for EMG activity for OI or OE.
Negative_regulation (less) of TrA in TrA
10) Confidence 0.02 Published 2004 Journal Spine Section Body Doc Link 15543074 Disease Relevance 0.05 Pain Relevance 0
In emphysematous hamsters, administration of ND decreased the activity of succinate:cytochrome c oxidoreductase compared with ND treatment in normal hamsters.
Negative_regulation (decreased) of oxidoreductase
11) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Abstract Doc Link PMC2706598 Disease Relevance 0.25 Pain Relevance 0
Oxidative fibers showed decreased NADH-TR activity, whereas that of glycolytic and oxidative-glycolytic type fibers increased.
Negative_regulation (decreased) of NADH-TR
12) Confidence 0.01 Published 2001 Journal Histochem. Cell Biol. Section Abstract Doc Link 11810194 Disease Relevance 0 Pain Relevance 0.16

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