INT10078

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Context Info
Confidence 0.50
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 4.23
Pain Relevance 5.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
neurons 6
striatum 4
brain 4
substantia nigra 3
cortex 3
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 31 100.00 Very High Very High Very High
withdrawal 12 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
Chronic pancreatitis 7 100.00 Very High Very High Very High
Dopamine 333 99.84 Very High Very High Very High
Substantia nigra 37 98.88 Very High Very High Very High
depression 5 98.68 Very High Very High Very High
Raphe 1 96.80 Very High Very High Very High
substance P 35 94.00 High High
Locus ceruleus 8 92.44 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 32 100.00 Very High Very High Very High
Pancreatitis 7 100.00 Very High Very High Very High
Disease 88 99.54 Very High Very High Very High
Bacterial Infection 2 99.34 Very High Very High Very High
Depression 5 98.68 Very High Very High Very High
Endotoxemia 1 86.32 High High
Exocrine Pancreatic Insufficiency 1 84.24 Quite High
Parkinson's Disease 24 80.36 Quite High
Eating Disorder 8 76.16 Quite High
Dyskinesias 136 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By immunohistochemistry, we observed a pronounced and patterned increase in proTRH immunostaining in the striatum, with the strongest proTRH expression concentrated in the lateral and ventrolateral striatum including the sensorimotor striatum.
Positive_regulation (increase) of Gene_expression (expression) of proTRH in striatum
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.45 Pain Relevance 0.29
In conscious rats subjected to endotoxic shock, thyrotropin releasing hormone (TRH) is shown to produce a rapid increase in cardiovascular variables and respiratory rates at intravenous doses between 0.20 and 6.34 mg/kg.
Positive_regulation (increase) of Gene_expression (produce) of TRH in respiratory associated with bacterial infection
2) Confidence 0.50 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6797829 Disease Relevance 0.26 Pain Relevance 0.22
TRH produced brief (5-15 min) but significant increases in latencies and thresholds without altering body temperature in both anterior and posterior PAG placements.
Positive_regulation (increases) of Neg (without) Gene_expression (produced) of TRH in body associated with central grey
3) Confidence 0.50 Published 1993 Journal Pain Section Abstract Doc Link 8278212 Disease Relevance 1.05 Pain Relevance 1.50
TRH-IR plasma levels in patients with CP and SEI (15.8 +/- 3) were significantly lower (p < 0.05) than in patients with normal pancreatic function (28.1 +/- 8), but were no different from those in patients with CP and moderate exocrine insufficiency (18.7 +/- 5).
Neg (no) Positive_regulation (different) of Gene_expression (levels) of TRH-IR in plasma associated with chronic pancreatitis
4) Confidence 0.49 Published 1992 Journal Hepatogastroenterology Section Abstract Doc Link 1459520 Disease Relevance 0.62 Pain Relevance 0.60
Measurement of HDC activity in the TMN and t-MH contents in the TMN, anterior hypothalamus and cortex after microinfusion of TRH into the TMN
Positive_regulation (contents) of Gene_expression (microinfusion) of TRH in cortex
5) Confidence 0.49 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.07 Pain Relevance 0.03
Change in food intake by different doses of TRH
Positive_regulation (doses) of Gene_expression (doses) of TRH
6) Confidence 0.49 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0 Pain Relevance 0
Taken together, the data suggest that Fos-like IR is induced within TRH-expressing neurons in the pPVN as a consequence of decreasing levels of circulating thyroid hormone (TH).
Positive_regulation (induced) of Gene_expression (expressing) of TRH in neurons
7) Confidence 0.47 Published 1991 Journal Endocrinology Section Abstract Doc Link 1954900 Disease Relevance 0.13 Pain Relevance 0.05
Our findings demonstrate that in the classic 6-OHDA model of PD, there is a strong up-regulation of expression of TRH in the dopamine-depleted striatum and its efferent projections to the pallidum and substantia nigra.
Positive_regulation (regulation) of Gene_expression (expression) of TRH in substantia nigra associated with dopamine, substantia nigra and disease
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.10 Pain Relevance 0.13
Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices.
Positive_regulation (recovery) of Gene_expression (recovery) of TRH in brain
9) Confidence 0.46 Published 1989 Journal Neuropeptides Section Title Doc Link 2575716 Disease Relevance 0 Pain Relevance 0.06
Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices.
Positive_regulation (increases) of Gene_expression (recovery) of TRH in brain
10) Confidence 0.46 Published 1989 Journal Neuropeptides Section Title Doc Link 2575716 Disease Relevance 0 Pain Relevance 0.06
Furthermore, the noradrenergic deficiency did not give rise to the development of the abnormal TSH response to TRH administration which is frequently observed in depression.
Positive_regulation (response) of Gene_expression (administration) of TRH associated with depression
11) Confidence 0.41 Published 1990 Journal Neurochem. Res. Section Abstract Doc Link 2325821 Disease Relevance 0.18 Pain Relevance 0.29
Further, we show that the enhanced expression of striatal proTRH was associated with the behavioral expression of motor complications in response to long-term L-DOPA therapy.
Positive_regulation (enhanced) of Gene_expression (expression) of proTRH
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.09 Pain Relevance 0.17
We conclude that 1) TRH is present throughout the gastrointestinal tract, with highest concentrations in the region distal to the LES; 2) TRH has no effect on basal LES tone; and 3) TRH inhibits the LES response to endogenously released and exogenous substance P but not the LES response to bethanechol.
Positive_regulation (concentrations) of Gene_expression (present) of TRH in LES associated with substance p
13) Confidence 0.25 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7681629 Disease Relevance 0 Pain Relevance 0.22
Exogenous TRH is capable of stimulating GH secretion in vivo, but this is only under particular developmental, experimental or pathological conditions (429, 430).
Positive_regulation (stimulating) of Gene_expression (capable) of TRH
14) Confidence 0.18 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.11 Pain Relevance 0.03
Measurement of HDC activity in the TMN and t-MH contents in the TMN, anterior hypothalamus and cortex after microinfusion of TRH into the TMN
Positive_regulation (contents) of in hypothalamus Gene_expression (microinfusion) of TRH in cortex
15) Confidence 0.17 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.07 Pain Relevance 0.03
In culture (from 2-week-old rats), TRH expression was stimulated by thyroid hormone and potentiated by glucocorticoids (426), whereas TRH gene expression was undetectable in cultures deprived of glucocorticoid (427).
Positive_regulation (stimulated) of Gene_expression (expression) of TRH in thyroid
16) Confidence 0.17 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.20 Pain Relevance 0.04
Our findings demonstrate that in the classic 6-OHDA model of PD, there is a strong up-regulation of expression of TRH in the dopamine-depleted striatum and its efferent projections to the pallidum and substantia nigra.
Positive_regulation (regulation) of in pallidum Gene_expression (expression) of TRH in substantia nigra associated with dopamine, substantia nigra and disease
17) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.10 Pain Relevance 0.13
Our previous study has shown that prothyrotropin-releasing hormone (proTRH) gene expression is increased in the ventrolateral periaqueductal gray (PAG) neurons following precipitated morphine withdrawal and continues to be activated even 24 h after withdrawal.
Positive_regulation (increased) of Gene_expression (expression) of proTRH in neurons associated with withdrawal, central grey and morphine
18) Confidence 0.06 Published 2001 Journal Brain Res. Section Abstract Doc Link 11701131 Disease Relevance 0.39 Pain Relevance 0.51
Our previous study has shown that prothyrotropin-releasing hormone (proTRH) gene expression is increased in the ventrolateral periaqueductal gray (PAG) neurons following precipitated morphine withdrawal and continues to be activated even 24 h after withdrawal.
Positive_regulation (activated) of Gene_expression (expression) of proTRH in neurons associated with withdrawal, central grey and morphine
19) Confidence 0.06 Published 2001 Journal Brain Res. Section Abstract Doc Link 11701131 Disease Relevance 0.42 Pain Relevance 0.54
Taken together, these results confirm that our model, based on available biochemical data from many independent studies of signalling pathways in the striatum, reproduces the changes in the phosphorylation levels of DARPP-32 at Thr34 and Thr75 produced by activation of dopamine-regulated second messenger pathways and changes in intracellular calcium concentration.


Positive_regulation (activation) of Gene_expression (produced) of Thr34 in striatum associated with dopamine
20) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.27

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