INT100783

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Context Info
Confidence 0.17
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6, CYP3A4) endoplasmic reticulum (CYP2B6, CYP3A4) oxidoreductase activity (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
Anatomy Link Frequency
liver 1
CYP2B6 (Homo sapiens)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 11 99.92 Very High Very High Very High
agonist 11 88.72 High High
fluoxetine 1 86.88 High High
Paracetamol 9 86.24 High High
Inflammation 16 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 8 99.92 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 27 99.20 Very High Very High Very High
Hyperglycemia 3 98.32 Very High Very High Very High
Diabetes Mellitus 17 96.52 Very High Very High Very High
Fatty Liver 63 92.28 High High
Fibrosis 8 90.80 High High
Adverse Drug Reaction 3 86.00 High High
Toxicity 5 83.20 Quite High
Disease Progression 3 63.20 Quite High
Hepatitis 1 47.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HepG2 cell lines that constitutively and stably express human CYP3A4 were constructed in order to study enzyme interactions with CYP3A4 as the only P450 present.
P450 Binding (interactions) of CYP3A4
1) Confidence 0.17 Published 2002 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 11811955 Disease Relevance 0 Pain Relevance 0.45
CYP3A4 is the most prominent P450 expressed in the human liver and metabolizes over 50% of all therapeutic drugs prescribed.
P450 Binding (metabolizes) of CYP3A4 in liver
2) Confidence 0.14 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 2.00 Pain Relevance 0.33

General Comments

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