INT100784

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (RYBP, CYP3A4) nucleoplasm (RYBP) small molecule metabolic process (CYP3A4)
endoplasmic reticulum (CYP3A4) intracellular (RYBP) enzyme binding (CYP3A4)
RYBP (Homo sapiens)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 18 100.00 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is the first report that APAP can increase CYP3A4 activity and content in transfected HepG2 cells.
APAP Positive_regulation (increase) of CYP3A4 associated with paracetamol
1) Confidence 0.44 Published 2002 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 11811955 Disease Relevance 0 Pain Relevance 0.76
In our models, APAP appears to increase CYP3A4 activity.
APAP Spec (appears) Positive_regulation (increase) of CYP3A4 associated with paracetamol
2) Confidence 0.26 Published 2002 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 11811955 Disease Relevance 0 Pain Relevance 0.78

General Comments

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