INT100799

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 7.33
Pain Relevance 12.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
synapses 3
cortex 2
spinal cord 1
amygdala 1
ACC neurons 1
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 680 100.00 Very High Very High Very High
Enkephalin 8 99.78 Very High Very High Very High
local anesthetic 4 99.52 Very High Very High Very High
Pain 37 99.48 Very High Very High Very High
Dorsal horn 35 99.44 Very High Very High Very High
long-term potentiation 432 99.20 Very High Very High Very High
nociceptor 3 99.20 Very High Very High Very High
Lasting pain 49 98.92 Very High Very High Very High
Anterior cingulate cortex 104 98.80 Very High Very High Very High
substance P 15 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 168 99.84 Very High Very High Very High
Aging 342 99.68 Very High Very High Very High
Pain 99 99.48 Very High Very High Very High
Disease 33 98.82 Very High Very High Very High
Anxiety Disorder 53 98.56 Very High Very High Very High
INFLAMMATION 25 97.56 Very High Very High Very High
Apoptosis 5 97.20 Very High Very High Very High
Depression 277 96.04 Very High Very High Very High
Cognitive Disorder 115 93.20 High High
Neuropathic Pain 21 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semi-quantitative RT-PCR studies on striatal tissue in the oldest age group confirmed the significant decrease in NR2A and also showed a decrease in NR2B.
Negative_regulation (decrease) of NR2A
1) Confidence 0.57 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.14 Pain Relevance 0.48
Cells that did not express NR2A contained both enkephalin and substance P, but proportionately more cells containing enkephalin displayed decreases in NR2A.
Negative_regulation (decreases) of NR2A associated with enkephalin and substance p
2) Confidence 0.57 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.30 Pain Relevance 0.51
The deficit of endogenous NT-3 induced a decrease in NR1 and NR2A subunits at postnatal day (P) 0 and P3 mice respectively, whereas an upregulation was observed in 12 week old NT-3 +/- mice.
Negative_regulation (decrease) of NR2A
3) Confidence 0.52 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.07 Pain Relevance 0.25
However, intrastriatal grafting of NT-3 secreting-cells in adult wild type mice produced a down-regulation of NR2A subunit.
Negative_regulation (regulation) of NR2A subunit
4) Confidence 0.52 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.05 Pain Relevance 0.21
Mice lacking Neto1 have a normal abundance of NR2B-containing NMDAR receptors but a reduction of NR2A-containing receptors at hippocampal excitatory synapses.
Negative_regulation (reduction) of NR2A-containing in synapses
5) Confidence 0.43 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.18
We hypothesized that animals deficient in GluRepsilon1, an abundant and ubiquitously postnatally expressed NMDAR subunit, might be resistant to the effects of ketamine.
Negative_regulation (deficient) of GluRepsilon1 associated with ketamine
6) Confidence 0.42 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385364 Disease Relevance 0.08 Pain Relevance 0.33
The inhibition of the N-methyl-D-aspartate receptor channel by local anesthetics in mouse CA1 pyramidal neurons.
Negative_regulation (inhibition) of N-methyl-D-aspartate receptor in pyramidal neurons associated with pyramidal cell, nmda receptor and local anesthetic
7) Confidence 0.41 Published 2002 Journal Anesth. Analg. Section Title Doc Link 11812692 Disease Relevance 0 Pain Relevance 0.75
A relatively selective NR1/NR2A antagonist, NVP-AAM077 (NVP) was developed recently and found to have more than 100-fold preferential blockade of NR1/NR2A vs NR1/NR2B [10].
Negative_regulation (blockade) of NR2A associated with antagonist
8) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.24 Pain Relevance 0.41
M) is not effective enough in inhibiting NR2A-containing NMDA receptors in ACC neurons.
Negative_regulation (inhibiting) of NR2A in ACC neurons associated with nmda receptor and anterior cingulate cortex
9) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0 Pain Relevance 0.19
Similarly, evidence suggests that a decrease in the NR2A/B ratio may facilitate open-eye potentiation, but again a causal role has yet to be demonstrated.
Negative_regulation (decrease) of NR2A in eye
10) Confidence 0.38 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.24 Pain Relevance 0.19
In the dorsal horn of KO mice, the amounts of NR2A and NR2B were decreased by 55% (P < 0.01) and 56% (P < 0.01), respectively, compared to those in WT mice.
Negative_regulation (decreased) of NR2A in dorsal horn associated with targeted disruption and dorsal horn
11) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.33 Pain Relevance 0.36
Viral-mediated overexpression of NR2A or RNAi knockdown of NR2B in the visual cortex specifically during the period of MD may be able to test this by preventing a decrease in the NR2A/B ratio.
Negative_regulation (decrease) of NR2A in cortex
12) Confidence 0.33 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.24 Pain Relevance 0.23
A study by Calon et al. (2005) showed that in a mouse model of AD with n-3 PUFA deficiency, the expression levels of GluN1, GluN2A and GluN2B subunits are significantly decreased compared to non-transgenic mice.
Negative_regulation (decreased) of GluN2A associated with targeted disruption and disease
13) Confidence 0.32 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.63 Pain Relevance 0.07
Consistent with the reduction in NR2A protein in the PSDs of Neto1-null mice, which had no change in total NR2A abundance in whole brain, we identified a decrease in NMDAR EPSCs at Schaffer collateral-CA1 synapses, which are normally dominated by NR2A-containing receptors [40].
Negative_regulation (reduction) of NR2A in synapses
14) Confidence 0.32 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
In this study, we examined the antinociceptive and motor effects of cone snail venom-derived peptides, conantokins G and T (conG and conT), which are selective inhibitors of the NR2B or NR2A and NR2B subtypes of the NMDA receptor, respectively.
Negative_regulation (inhibitors) of NR2A associated with nmda receptor and antinociceptive
15) Confidence 0.31 Published 2003 Journal Pain Section Abstract Doc Link 12507705 Disease Relevance 0.51 Pain Relevance 0.59
Similarly, in mice lacking the C terminus of NR2A, the initial acquisition in the Morris water maze is normal but, like the NR2A-null, these mice also have impaired spatial working memory [55].
Negative_regulation (impaired) of NR2A-null
16) Confidence 0.31 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.08
Consequently, if the decrease in NMDAR EPSCs was due to the reduced level of NR2A-NMDARs, the relative contribution of NR2B-NMDARs to synaptic NMDAR currents would be predicted to be increased in Neto1-null mice.
Negative_regulation (reduced) of NR2A
17) Confidence 0.31 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.16
These results indicate that both NR2A and NR2B-containing NMDA receptors were impaired in transgenic CA1 hippocampal neurons.


Negative_regulation (impaired) of NR2A in neurons associated with targeted disruption and nmda receptor
18) Confidence 0.30 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.16 Pain Relevance 0.56
The mechanism by which the NR2A/B ratio changes is determined by the length of dark exposure: short periods shift the ratio through increasing NR2B levels, whereas with longer periods NR2B protein levels return to normal and NR2A levels decrease (Chen & Bear 2007).
Negative_regulation (decrease) of NR2A
19) Confidence 0.28 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.06 Pain Relevance 0.22
Western blots show a reduction in phosphorylated-NR1, NR2A, and NR2B subunit protein expression in the amygdala from fear-conditioned animals.
Negative_regulation (reduction) of NR2A in amygdala associated with anxiety disorder and amygdala
20) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.76 Pain Relevance 0.67

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