INT100804

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Context Info
Confidence 0.18
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
cytoplasm (Ppp1cc) chromosome (Ppp1cc) nucleolus (Ppp1cc)
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 7 95.70 Very High Very High Very High
agonist 2 95.56 Very High Very High Very High
Morphine 4 95.32 Very High Very High Very High
Potency 1 83.16 Quite High
Opioid receptor 1 1 68.40 Quite High
Hippocampus 1 58.48 Quite High
cerebral cortex 1 57.84 Quite High
Dopamine 119 55.40 Quite High
Glutamate 31 42.64 Quite Low
nMDA receptor 2 20.20 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The net effects of these different calcium inputs on the PKAc:PP1 balance are summarized in Figure S2B.
Regulation (effects) of Gene_expression (balance) of PP1
1) Confidence 0.18 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.03
Up-regulation of KEPI expression by morphine, an agonist at PKC-regulating G-protein-coupled mu receptors, provides a novel signaling paradigm in which the half-lives of serine/threonine phosphorylation events can be influenced by activities at G(i)/G(o)-coupled receptors that modulate KEPI expression, KEPI phosphorylation, and KEPI regulation of PP1 activity.
Regulation (modulate) of Gene_expression (expression) of PP1 associated with kinase c, agonist and morphine
2) Confidence 0.16 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.57

General Comments

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