INT100805

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.77
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
cytoplasm (Ppp1cc) chromosome (Ppp1cc) nucleolus (Ppp1cc)
Anatomy Link Frequency
dorsal root ganglia 1
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 150 98.92 Very High Very High Very High
depression 78 98.64 Very High Very High Very High
Opioid receptor 1 1 98.24 Very High Very High Very High
Kinase C 14 95.64 Very High Very High Very High
Morphine 5 92.44 High High
Hippocampus 26 88.32 High High
cerebral cortex 1 87.68 High High
Nucleus accumbens 3 77.76 Quite High
Potency 1 76.88 Quite High
Thalamus 1 70.32 Quite High
Disease Link Frequency Relevance Heat
Depression 78 98.64 Very High Very High Very High
Targeted Disruption 180 93.76 High High
Anxiety Disorder 56 73.84 Quite High
Pain 4 41.36 Quite Low
Hypesthesia 2 30.00 Quite Low
Shock 14 27.84 Quite Low
Nociception 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To improve understanding of KEPI's role in the brain, we have developed anti-KEPI sera in rabbits immunized with a hemocyanin conjugate of KEPI residues 66-80, characterized the specificity that this serum provides, mapped the distribution of immunoreactive KEPI (iKEPI) in mouse brain, rat dorsal root ganglia and striatal cultures and documented KEPI binding to PP1 in vitro.
PP1 Binding (binding) of in dorsal root ganglia
1) Confidence 0.47 Published 2005 Journal Neuroscience Section Abstract Doc Link 15837133 Disease Relevance 0 Pain Relevance 0.42
Fourth, neurabin-binding PP1 may not directly modulate LTP or LTD.
PP1 Binding (binding) of associated with depression and long-term potentiation
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.14 Pain Relevance 0.62
Using virus-mediated expression of mutant neurabin, which is unable to bind PP1 or F-actin, it was found to attenuate LTD, increase LTP and decrease basal synaptic transmission in hippocampal slice culture [25], [26].
PP1 Neg (unable) Binding (bind) of associated with depression and long-term potentiation
3) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.63 Pain Relevance 0.44
Thus the model uses the same dephosphorylation rates for PP1 bound and unbound phosphoThr34 to reproduce experimental measurements.
PP1 Binding (bound) of
4) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
Since the Thr34 phosphorylated site of DARPP-32 binds to the active zone of PP1 [109], the rate of dephosphorylation of phosphoThr34 by PP2B is probably decreased when bound to PP1.
PP1 Binding (bound) of
5) Confidence 0.15 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
No qualitative changes in the results are seen if the dephosphorylation rate is decreased 50% when phosphoThr34 is bound to PP1.
PP1 Binding (bound) of
6) Confidence 0.15 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
Nonetheless, the very high affinity of phosphoThr34 for PP1 implies that almost all phosphoThr34 is bound to PP1, and if Thr34 can be dephosphorylated only when unbound, phosphoThr34 increases to the amount of PP1.
PP1 Binding (bound) of
7) Confidence 0.15 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
When DARPP-32 is phosphorylated at Thr34 it binds to and inactivates PP1, with an affinity of 1 nM [14].
PP1 Binding (binds) of
8) Confidence 0.14 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.05
These sequences displayed sufficient homology with the porcine PP1 inhibitor CPI-17 that we asked whether KEPI could share the ability of CPI-17 to modulate PP1 activity in a PKC-dependent fashion.
PP1 Spec (asked) Binding (homology) of associated with kinase c
9) Confidence 0.13 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.69

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