INT100812

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PPP1R14C)
PPP1R14C (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 24 99.84 Very High Very High Very High
Potency 4 98.98 Very High Very High Very High
agonist 4 95.04 Very High Very High Very High
Morphine 16 94.80 High High
Opioid receptor 1 4 91.08 High High
Hippocampus 4 81.16 Quite High
cerebral cortex 4 80.52 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant mouse KEPI is phosphorylated by PKC with a K(m) of 2.6 microm and a t(1/2) of 20 min.
Phosphorylation (phosphorylated) of KEPI associated with kinase c
1) Confidence 0.71 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.66
Up-regulation of KEPI expression by morphine, an agonist at PKC-regulating G-protein-coupled mu receptors, provides a novel signaling paradigm in which the half-lives of serine/threonine phosphorylation events can be influenced by activities at G(i)/G(o)-coupled receptors that modulate KEPI expression, KEPI phosphorylation, and KEPI regulation of PP1 activity.
Phosphorylation (phosphorylation) of KEPI associated with kinase c, agonist and morphine
2) Confidence 0.62 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.57
Phospho-KEPI inhibits PP1alpha with an IC(50) of 2.7 nm, a potency more than 600-fold greater than that displayed by unphosphorylated KEPI.
Phosphorylation (unphosphorylated) of KEPI associated with potency
3) Confidence 0.47 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.66
Up-regulation of KEPI expression by morphine, an agonist at PKC-regulating G-protein-coupled mu receptors, provides a novel signaling paradigm in which the half-lives of serine/threonine phosphorylation events can be influenced by activities at G(i)/G(o)-coupled receptors that modulate KEPI expression, KEPI phosphorylation, and KEPI regulation of PP1 activity.
Phosphorylation (phosphorylation) of KEPI associated with kinase c, agonist and morphine
4) Confidence 0.47 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.57

General Comments

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