INT100816

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PPP1R14C, Ppp1cc) mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc)
protein complex (Ppp1cc) chromosome (Ppp1cc) nucleolus (Ppp1cc)
PPP1R14C (Homo sapiens)
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 12 99.40 Very High Very High Very High
Opioid receptor 1 2 95.48 Very High Very High Very High
agonist 2 94.52 High High
Morphine 8 94.28 High High
Hippocampus 2 85.56 High High
cerebral cortex 2 84.92 Quite High
Potency 2 84.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of KEPI expression by morphine, an agonist at PKC-regulating G-protein-coupled mu receptors, provides a novel signaling paradigm in which the half-lives of serine/threonine phosphorylation events can be influenced by activities at G(i)/G(o)-coupled receptors that modulate KEPI expression, KEPI phosphorylation, and KEPI regulation of PP1 activity.
KEPI Regulation (regulation) of PP1 associated with kinase c, agonist and morphine
1) Confidence 0.08 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.56
These sequences displayed sufficient homology with the porcine PP1 inhibitor CPI-17 that we asked whether KEPI could share the ability of CPI-17 to modulate PP1 activity in a PKC-dependent fashion.
KEPI Regulation (modulate) of PP1 associated with kinase c
2) Confidence 0.08 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.71

General Comments

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