INT100821

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 59
Total Number 61
Disease Relevance 45.26
Pain Relevance 11.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
neutrophils 6
microglia 4
lymphocytes 3
lens 2
monocytes 2
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1094 100.00 Very High Very High Very High
cytokine 492 100.00 Very High Very High Very High
chemokine 73 100.00 Very High Very High Very High
Inflammatory mediators 62 100.00 Very High Very High Very High
metalloproteinase 170 99.92 Very High Very High Very High
Arthritis 82 99.78 Very High Very High Very High
qutenza 63 99.78 Very High Very High Very High
depression 25 99.18 Very High Very High Very High
cINOD 131 98.62 Very High Very High Very High
fibrosis 190 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1221 100.00 Very High Very High Very High
Shock 28 99.82 Very High Very High Very High
Arthritis 105 99.78 Very High Very High Very High
Hypoxia 13 99.78 Very High Very High Very High
Stress 402 99.70 Very High Very High Very High
Pneumonia 67 99.54 Very High Very High Very High
Drug Induced Neurotoxicity 40 99.48 Very High Very High Very High
Disease 995 99.38 Very High Very High Very High
Injury 284 99.36 Very High Very High Very High
Peptic Ulcer 9 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If LEC loss and the accumulation of cortical nuclear fragments and ROS are instrumental in ARC progress, exogenous agents capable of damaging LECs, and inducing oxidative damage, would be expected to produce the same series of events in an accelerated fashion.
Localization (accumulation) of ROS associated with aids-related complex
1) Confidence 0.60 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2925908 Disease Relevance 0.56 Pain Relevance 0
Furosemide, producing a smaller metabolic demand as a result of the depression of the cochlear amplifier, leads to the release of lower levels of ROS, with less damage, whereas anti-oxidants counteract the elevated ROS levels induced by the noise exposure.
Localization (release) of ROS in cochlear associated with depression
2) Confidence 0.55 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.38 Pain Relevance 0.11
These considerations support the suggestion that the NIHL following exposure to broadband noise is due to excessive release of ROS which disrupts sensitive elements in the cochlea.
Localization (release) of ROS in cochlea associated with noise-induced hearing loss
3) Confidence 0.55 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.34 Pain Relevance 0.08
The anti-oxidants serve to reduce harmful effects of the excessive release of free radicals (such as reactive oxygen species, ROS) which occurs during and after the noise exposure.
Localization (release) of ROS
4) Confidence 0.48 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.05 Pain Relevance 0.06
Kupffer cells release reactive oxygen species (ROS), cytokines, and chemokines, which induce neutrophil extravasation and activation.
Localization (release) of ROS in neutrophil associated with chemokine and cytokine
5) Confidence 0.41 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11812920 Disease Relevance 0.98 Pain Relevance 0.22
Method of exposure to ROS
Localization (exposure) of ROS
6) Confidence 0.34 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.07 Pain Relevance 0
Vascular relaxation in the ROS scavenger pretreatment
Localization (pretreatment) of ROS
7) Confidence 0.34 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.15 Pain Relevance 0.10
These data demonstrate that capsaicin initiates ROS generation through TRPV1 activation.
Localization (generation) of ROS associated with qutenza
8) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.06 Pain Relevance 0.45
In spite of the initial recovery of DNA strand breaks, a dysfunctional lens status increased over time as confirmed by confocal viewing of living lenses using fluorescent dyes for nuclear fragments, free DNA presence, and localized ROS presence as well as noting aberrant LEC migration within the lens.
Localization (localized) of ROS in lens
9) Confidence 0.24 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254966 Disease Relevance 0.24 Pain Relevance 0
In spite of the initial recovery of DNA strand breaks, a dysfunctional lens status increased over time as confirmed by confocal viewing of living lenses using fluorescent dyes for nuclear fragments, free DNA presence, and localized ROS presence as well as noting aberrant LEC migration within the lens.
Localization (presence) of ROS in lens
10) Confidence 0.21 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254966 Disease Relevance 0.24 Pain Relevance 0
Vascular relaxation in the ROS scavenger pretreatment
Localization (pretreatment) of ROS
11) Confidence 0.20 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2926425 Disease Relevance 0.16 Pain Relevance 0.12
Hypothalamic pieces were carefully homogenized using a dounce and loaded with the dichlorodihydro-fluorescein diacetate probe that is oxidized to fluorescent dichlorofluorescein by H2O2 and classically used to monitor intracellular generation of ROS (CM-H2DCFDA, Molecular Probes).
Localization (generation) of ROS
12) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0 Pain Relevance 0
The aim of the present study was to investigate the involvement of the ROS released by inflammatory cells during the development of pulmonary fibrosis and to consider the consequence on MMP/TIMP balances.
Localization (released) of ROS associated with fibrosis, inflammation and pulmonary fibrosis
13) Confidence 0.15 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.64 Pain Relevance 0.35
At day 1, ROS release by BAL cells from bleomycin-treated WT mice was accompanied by a significant neutrophil influx, but the total BAL cell count did not rise (Table 1).
Localization (release) of ROS in neutrophil
14) Confidence 0.15 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.07 Pain Relevance 0
This study used the following materials, from the manufacturers mentioned: bleomycin sulfate from Bellon Laboratories (Montrouge, France); gelatin, Triton X-100, Coomassie Brilliant Blue, EDTA, Tween 20 solution, hydroxyproline, and trypan blue from Sigma (St Louis, MO, USA); May-Grünwald and Giemsa stains from RAL (Paris, France); sodium pentobarbital from Sanofi Santé Animale (Libourne, France); etomidate (Hypnomidate®, 2 mg/mL) from Janssen-Cilag (Issy-les-Moulineaux, France); acrylamide, sodium dodecyl sulfate (SDS), Tris, and BSA from Eurobio (Les Ulis, France); ELISA kits for IL-6, TIMP-1, and pro-MMP-9 detection from R&D Systems (Minneapolis, MN, USA); formaldehyde from Merck (Darmstadt, Germany); isopentane from Prolabo (Fontenay-sous-Bois, France); a low-range weight marker for SDS-PAGE from Biorad (Munich, Germany); and an ABEL® chemiluminescence kit for measurement of in vitro ROS release from Knight Scientific Limited (Plymouth, UK).


Localization (release) of ROS
15) Confidence 0.15 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.20 Pain Relevance 0.11
During lung inflammation, activated phagocytes release large amounts of reactive oxygen species (ROS), which may be involved in tissue injury and in impeding tissue repair, both of which lead to pulmonary fibrosis [4-6].
Localization (release) of ROS in phagocytes associated with fibrosis, inflammation, injury, pulmonary fibrosis and pneumonia
16) Confidence 0.15 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.86 Pain Relevance 0.46
Viral proteins including the HBV X and HCV core proteins are capable of inducing ROS accumulation in hepatocytes [73].
Localization (accumulation) of ROS in hepatocytes associated with hepatitis b virus infection and hepatitis c virus infection
17) Confidence 0.13 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.26 Pain Relevance 0.11
is dependent on ROS accumulation.
Localization (accumulation) of ROS
18) Confidence 0.13 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.17 Pain Relevance 0.11
ROS released from infiltrating inflammatory cells is implicated in the breakdown of cartilage and bone in RA, and elevated levels of MDA have been observed in the serum and synovial fluid of RA patients [31].
Localization (released) of ROS in cartilage associated with inflammation and rheumatoid arthritis
19) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2841253 Disease Relevance 1.20 Pain Relevance 0.66
Thus, a treatment of scavenger of ROS is expected to prevent these free radical mediated liver diseases.
Localization (scavenger) of ROS in liver associated with liver disease
20) Confidence 0.11 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 1.02 Pain Relevance 0.28

General Comments

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