INT100822

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Context Info
Confidence 0.74
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.13
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
blood 1
plasma 1
adipose tissue 1
olfactory bulb 1
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 18 98.90 Very High Very High Very High
Inflammatory response 16 83.84 Quite High
cytokine 49 82.32 Quite High
Inflammation 68 82.28 Quite High
chemokine 5 81.12 Quite High
cva 5 75.72 Quite High
Action potential 3 69.76 Quite High
Paracetamol 2 56.96 Quite High
withdrawal 5 25.00 Low Low
Central nervous system 3 8.08 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 215 99.68 Very High Very High Very High
Obesity 24 99.60 Very High Very High Very High
Aging 111 99.16 Very High Very High Very High
Death 93 98.64 Very High Very High Very High
Disease 45 98.32 Very High Very High Very High
Congenital Anomalies 2 97.76 Very High Very High Very High
Autoimmune Disease 19 96.32 Very High Very High Very High
Stress 43 95.68 Very High Very High Very High
Toxicity 4 93.92 High High
Cerebral Malaria 26 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, because loss of one allele of Bim synergizes with Fas deficiency to cause immunopathology, it is possible that combinations of mutant alleles of Bim and Fas, which by themselves do not cause readily identifiable abnormalities, may underlie certain autoimmune diseases in humans.
Localization (alleles) of Fas associated with autoimmune disease and congenital anomalies
1) Confidence 0.74 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.86 Pain Relevance 0
In cholestatic disease, endogenously generated bile acids produce hepatocellular apoptosis by stimulating Fas translocation from the cytoplasm to the plasma membrane where self-aggregation occurs to trigger apoptosis.
Localization (translocation) of Fas in plasma associated with bile, apoptosis and disease
2) Confidence 0.62 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11812920 Disease Relevance 0.85 Pain Relevance 0.19
In wild type mice, Fas ligand positive cells are localized around the vasculature and particularly in the olfactory bulb.
Localization (localized) of Fas in olfactory bulb
3) Confidence 0.38 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.74 Pain Relevance 0.07
FAS-deficient mice reveal a phenotype resembling PPAR?
Localization (resembling) of FAS
4) Confidence 0.30 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.24 Pain Relevance 0.06
Because Fas did not localize to lipid rafts with aging during AICD, in contrast with young subjects, we can hypothesize that the formation of the death-inducing signaling complex (DISC) is also impaired in the elderly (Larbi, Muti, et al 2006).
Neg (not) Localization (localize) of Fas associated with aging and death
5) Confidence 0.20 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.07 Pain Relevance 0
activation by FAs released from the adipose tissue leads to induction of several metabolic processes in mice: ?
Localization (released) of FAs in adipose tissue associated with obesity
6) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.54 Pain Relevance 0.04
In particular during fasting, when free FAs are released into the blood, endogenous lipid-activation is of importance.
Localization (released) of FAs in blood
7) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.71 Pain Relevance 0.08
The negatively regulated genes included FAS, TNFR, COL6A1, JAM2, FOXQ1, FOXO1, NESTIN, SMAD3, SLIT3, DKK1, WNT5A, BMP1, and GLIS3 which are implicated in differentiation processes as well as a number of novel genes.
Localization (implicated) of FAS
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2747014 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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