INT100823

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.22
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) mitochondrion (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1) cell proliferation (Ros1) signal transduction (Ros1)
Cyp2e1 (Mus musculus)
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1 94.36 High High
cytokine 1 93.72 High High
Paracetamol 1 89.52 High High
Bile 1 81.64 Quite High
withdrawal 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 2 95.20 Very High Very High Very High
Injury 2 91.16 High High
Toxicity 2 88.40 High High
Apoptosis 3 88.24 High High
Disease 1 80.48 Quite High
Hepatotoxicity 3 75.00 Quite High
Targeted Disruption 1 74.64 Quite High
Nash(non-alcoholic Steatohepatitis) 2 62.00 Quite High
Hepatitis 1 57.92 Quite High
Parkinson's Disease 1 56.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP2E1 generates ROS, activates many toxicologically important substrates, and may be the central pathway by which ethanol causes oxidative stress.
CYP2E1 Positive_regulation (generates) of ROS associated with stress
1) Confidence 0.35 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11812920 Disease Relevance 1.22 Pain Relevance 0.22

General Comments

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