INT100861

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 10
Speculated 6
Reported most in Body
Documents 179
Total Number 187
Disease Relevance 175.20
Pain Relevance 26.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 6
coronary artery 4
liver 4
platelets 3
thyroid 3
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2430 100.00 Very High Very High Very High
Inflammatory marker 291 100.00 Very High Very High Very High
Pain 74 100.00 Very High Very High Very High
Arthritis 462 99.84 Very High Very High Very High
cytokine 473 99.80 Very High Very High Very High
rheumatoid arthritis 780 99.60 Very High Very High Very High
Angina 414 99.24 Very High Very High Very High
Inflammatory response 106 98.96 Very High Very High Very High
cva 147 98.50 Very High Very High Very High
depression 44 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2850 100.00 Very High Very High Very High
Diabetes Mellitus 1749 100.00 Very High Very High Very High
Obesity 1360 100.00 Very High Very High Very High
Nicotine Addiction 1195 100.00 Very High Very High Very High
Atherosclerosis 1156 100.00 Very High Very High Very High
Disease 1073 100.00 Very High Very High Very High
Cardiovascular Disease 725 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 603 100.00 Very High Very High Very High
Obstructive Sleep Apnea 163 100.00 Very High Very High Very High
Pain 57 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, there was no strong statistical evidence that these haplotypes influencing serum CRP levels were related to CIMT after taking into account the magnitude of their association with CRP.
CRP Binding (association) of
1) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.43 Pain Relevance 0
C-reactive protein (CRP), a marker of systemic inflammation, is associated with risk of coronary events and sub-clinical measures of atherosclerosis.
CRP Binding (associated) of associated with inflammation and atherosclerosis
2) Confidence 0.48 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.40 Pain Relevance 0.05
In these analyses we used a model for the haplotype-CRP association that assumes each of a participant's two haplotypes contributes additively to his/her value of CRP, as done in a previous study that used similar CRP haplotypes as instruments for the effect of CRP on components of the metabolic syndrome [20].
CRP Binding (association) of associated with metabolic syndrome
3) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.09 Pain Relevance 0
In a recent prospective nested case control study there were no associations between four out of five common haplotypes in CRP with CHD risk, despite associations of these haplotypes with CRP levels.[13] The only haplotype that was associated with CHD risk in that study showed an association in the opposite direction to that predicted by its association with CRP levels; the haplotype was associated with lower CRP levels but greater CHD risk.[13] In another study that typed 7 SNPs in CRP there were no associations with CHD events except in one sub-group analysis: AA genotype of the triallelic SNP rs3091244 was associated with prevalent coronary heart disease in non-Hispanic white individuals.[18] Such sub-group analyses should be treated with caution unless replicated in independent samples.
CRP Binding (association) of in heart associated with cv unclassified under development
4) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.10 Pain Relevance 0
Genetic variants that are known to be associated with CRP levels can be used to provide causal inference of the effect of CRP on CHD.
CRP Binding (associated) of associated with cv unclassified under development
5) Confidence 0.48 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.58 Pain Relevance 0
Efstratiadis et al. discovered that after controlling for BMI and various CRP confounders, diabetes was not associated with CRP [30].
CRP Binding (associated) of associated with diabetes mellitus and obesity
6) Confidence 0.48 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.68 Pain Relevance 0.04
Racial differences were found for the association of waist circumference and CRP, highlighting the need for a better understanding of the significance of CRP and clinical relevance of values for various ethnicities and races.
CRP Binding (association) of
7) Confidence 0.48 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.01 Pain Relevance 0.03
A Swedish cross-sectional study that investigated the relationship between CRP, sub-clinical atherosclerosis and various cardiovascular risk factors found CS consumption to be the variable that showed the strongest association with CRP levels (

Hulthe and others, 2001

).


CRP Binding (association) of associated with atherosclerosis
8) Confidence 0.47 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 0.56 Pain Relevance 0.08
To date, levels of systemic TNF alpha, Rheumatoid Factor, anti-CCP antibodies and C-Reactive Protein have been analyzed for their association with treatment response, but the results have shown either inconsistent or with no practical use in the clinical setting [8].
C-Reactive Protein Spec (analyzed) Binding (association) of
9) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2762038 Disease Relevance 0 Pain Relevance 0.08
large positive associations between ambient BC, NO2, and O3 and CRP and IL-6, as shown for the 5-day moving average concentrations
CRP Binding (associations) of
10) Confidence 0.46 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 1.37 Pain Relevance 0.27
enhanced associations with CRP, IL-6, and WBCs.
CRP Binding (associations) of
11) Confidence 0.46 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1513328 Disease Relevance 1.52 Pain Relevance 0.15
timing of the association between PM and CRP for our
CRP Binding (association) of
12) Confidence 0.46 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 0.65 Pain Relevance 0.13
C-reactive protein (CRP), a marker of systemic inflammation, is associated with risk of coronary events and sub-clinical measures of atherosclerosis.
C-reactive protein Binding (associated) of associated with inflammation and atherosclerosis
13) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507732 Disease Relevance 0.40 Pain Relevance 0.05
Regarding the association between thyroid hormone levels and serum CRP, previous studies have reflected conflicting observations.
serum CRP Binding (association) of in thyroid
14) Confidence 0.42 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.40 Pain Relevance 0.09
For men without diabetes the association between waist circumference and BMI with hs-CRP was much stronger than for men with diabetes.
hs-CRP Binding (association) of associated with diabetes mellitus and obesity
15) Confidence 0.42 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.42 Pain Relevance 0.04
After adjustment for age, smoking, diabetes status and medication use (NSAID, cholesterol, hypertension and depression medications), MLR revealed that WC, BMI, and gender were all significantly associated with ln hs-CRP (P < 0.05) (Tables 2 and 3).
hs-CRP Binding (associated) of associated with nicotine addiction, depression, diabetes mellitus, obesity, hypertension and cinod
16) Confidence 0.42 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 2.06 Pain Relevance 0.29
After adjusting for traditional risk factors such as hypertension, diabetes, gender, age, and BMI, the significant association between hsCRP and risk of repeat coronary events remained for individuals in the top hsCRP quartile (OR 3.9, 95%CI 1.41–10.8; P = .009; Model 2, Table 4).
hsCRP Binding (association) of associated with diabetes mellitus, obesity and hypertension
17) Confidence 0.41 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC2989863 Disease Relevance 1.05 Pain Relevance 0
Elevated CRP has been associated with undiagnosed peripheral, coronary, and cerebral artery disease; it differentiates patients with unstable versus stable angina; predicts future MI, stroke and sudden cardiac death in patients with coronary artery disease; correlates with MI; and predicts the presence, degree, and symptomatology of carotid stenosis, as well as early morbidity and late mortality following coronary artery bypass grafting, and late restenosis following percutaneous cardiac interventions.
CRP Binding (associated) of in coronary artery associated with cerebral arterial diseases, angina, coronary artery disease, cardiovascular disease, stroke, cv unclassified under development and myocardial infarction
18) Confidence 0.38 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.89 Pain Relevance 0.43
This null finding is assumed to represent a non-confounded and unbiased estimate of the association between CRP and CIMT because the existence of early stages of atherosclerosis cannot alter inherited haplotypes [15], and the potential confounders of the CRP-atherosclerosis association (e.g., obesity, smoking, physical inactivity or socioeconomic adversity) were distributed evenly among the different CRP haplotypes.
CRP Binding (association) of associated with nicotine addiction, atherosclerosis and metabolic syndrome
19) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.48 Pain Relevance 0
For these reasons, it seems unlikely that population stratification would have masked a causal association between CRP and CIMT.
CRP Binding (association) of
20) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0 Pain Relevance 0

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