INT100870

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.24
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
plasma 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 100.00 Very High Very High Very High
Angina 1 93.52 High High
cva 1 60.08 Quite High
Inflammation 29 50.00 Quite Low
cytokine 13 27.40 Quite Low
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 38 96.92 Very High Very High Very High
Cv General 3 Under Development 2 93.52 High High
Increased Venous Pressure Under Development 19 92.08 High High
Diabetes Mellitus 83 87.60 High High
Atherosclerosis 3 76.00 Quite High
Disease 7 75.00 Quite High
Cardiovascular Disease 8 64.16 Quite High
Adhesions 16 50.16 Quite High
Apoptosis 89 50.00 Quite Low
INFLAMMATION 29 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fibrin formed from plasma collected during and immediately post CABG was associated with increased fibrinolytic capacity and enhanced binding of a) MMP-9, b) the low Mw protease triplet (described above), and c) PA (as putative 110-kDa tPA:PAI-1 complex).
Positive_regulation (increased) of PAI-1 Binding (binding) of in plasma associated with metalloproteinase
1) Confidence 0.49 Published 2001 Journal Inflammation Section Abstract Doc Link 11820459 Disease Relevance 0.24 Pain Relevance 0.18
A supportive finding for this hypothesis is the fact that VEGF receptor 1 (FLT1) and PAI-1, both known Egr-1 responsive genes, are also increased in the presence of glucose and insulin.
Positive_regulation (increased) of PAI-1 Binding (receptor) of
2) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.00 Pain Relevance 0.03

General Comments

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