INT100874

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.51
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plau) signal transduction (Plau) extracellular space (Plau)
extracellular region (Plau) kinase activity (Plau)
Anatomy Link Frequency
dorsal horn 2
ECM 1
Plau (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 10 97.72 Very High Very High Very High
Neuropathic pain 4 96.56 Very High Very High Very High
Sciatic nerve 13 90.96 High High
intrathecal 2 90.88 High High
metalloproteinase 5 86.04 High High
Peripheral nerve injury 6 84.00 Quite High
Dorsal horn neuron 4 81.92 Quite High
long-term potentiation 2 76.76 Quite High
Thermal hyperalgesia 2 75.76 Quite High
Pain 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 96.56 Very High Very High Very High
Cancer 1 96.00 Very High Very High Very High
Metastasis 2 94.40 High High
Nervous System Injury 6 84.00 Quite High
Nociception 2 82.44 Quite High
Hyperalgesia 2 75.76 Quite High
Pain 5 75.00 Quite High
Disease 3 75.00 Quite High
Atherosclerosis 1 75.00 Quite High
Cv General 3 Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As neither immunoreactivity for uPA nor uPA-mediated proteolysis was observed, we further examined the effects of tPA on dorsal horn excitability and neuropathic pain behaviour.
Protein_catabolism (proteolysis) of uPA in dorsal horn associated with neuropathic pain and dorsal horn
1) Confidence 0.77 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.54 Pain Relevance 0.81
The cell proliferation and differentiation process is also an event involving uPA catalytic ECM degradation that increases cell migration by activating MMP 9 [21].
Protein_catabolism (degradation) of uPA in ECM
2) Confidence 0.58 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.27 Pain Relevance 0.03
As neither immunoreactivity for uPA nor uPA-mediated proteolysis was observed, we further examined the effects of tPA on dorsal horn excitability and neuropathic pain behaviour.
Protein_catabolism (proteolysis) of uPA in dorsal horn associated with neuropathic pain and dorsal horn
3) Confidence 0.51 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.54 Pain Relevance 0.81
Electrophoresis (8.5% SDS-PAGE) revealed that fibrin formed in the presence of ACP demonstrated characteristic gamma-gamma dimers (90-kDa) and beta-monomers (55-kDa), but resisted spontaneous fibrinolysis (72 h, 37 degrees C) or degradation by plasminogen activators (uPA, tPA).
Protein_catabolism (degradation) of uPA
4) Confidence 0.04 Published 2001 Journal Inflammation Section Abstract Doc Link 11820459 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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