INT100892

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.44
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCLC) small molecule metabolic process (GCLC) cellular nitrogen compound metabolic process (GCLC)
ligase activity (GCLC) cytoplasm (GCLC)
Anatomy Link Frequency
colon 1
oviducts 1
oocytes 1
GCLC (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 100.00 Very High Very High Very High
cINOD 18 99.20 Very High Very High Very High
Inflammation 22 90.84 High High
corticosteroid 38 64.60 Quite High
antagonist 8 50.00 Quite Low
Inflammatory response 1 32.20 Quite Low
endometriosis 84 5.00 Very Low Very Low Very Low
cytokine 42 5.00 Very Low Very Low Very Low
Dismenorea 10 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 189 98.90 Very High Very High Very High
Recurrence 10 98.76 Very High Very High Very High
INFLAMMATION 33 98.48 Very High Very High Very High
Colon Cancer 3 97.36 Very High Very High Very High
Stress 220 90.24 High High
Eclampsia 40 84.16 Quite High
Hydatidiform Mole 8 82.64 Quite High
Congenital Anomalies 8 78.80 Quite High
Pathologic Processes 4 73.80 Quite High
Asthma 80 53.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simultaneous incubation with the thiol antioxidant N-acetylcysteine (NAC) inhibited indomethacin-mediated increases in GCLC mRNA, suggesting that increases in GCLC message were triggered by changes in intracellular oxidation/reduction (redox) reactions.
Positive_regulation (increases) of GCLC
1) Confidence 0.68 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.07 Pain Relevance 0.14
These results also support the hypothesis that indomethacin-induced transcriptional activation of GCLC involves the redox-dependent release of KIAA0132 from Nrf2 followed by the nuclear translocation of Nrf2.
Positive_regulation (activation) of GCLC
2) Confidence 0.59 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.09
Consistent with this idea, over-expression of Nrf2 increased GCLC reporter gene expression and over-expression of KIAA0132 inhibited GCLC reporter gene activity as well as inhibited indomethacin-induced increases in the expression of GCLC.
Positive_regulation (increases) of GCLC
3) Confidence 0.46 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.08
Simultaneous incubation with the thiol antioxidant N-acetylcysteine (NAC) inhibited indomethacin-mediated increases in GCLC mRNA, suggesting that increases in GCLC message were triggered by changes in intracellular oxidation/reduction (redox) reactions.
Positive_regulation (increases) of GCLC
4) Confidence 0.40 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.07 Pain Relevance 0.14
Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.
Positive_regulation (Induction) of gamma-glutamylcysteine synthetase in colon associated with inflammation, colon cancer, cinod and cox2
5) Confidence 0.16 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11820781 Disease Relevance 0.65 Pain Relevance 0.57
The expression profiles of the transcripts of the antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and gamma-glutamylcysteine synthetase in both human and mouse oviducts and oocytes have also been examined [16].
Positive_regulation (superoxide) of gamma-glutamylcysteine synthetase in oocytes
6) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.59 Pain Relevance 0
The expression profiles of the transcripts of the antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and gamma-glutamylcysteine synthetase in both human and mouse oviducts and oocytes have also been examined [16].
Positive_regulation (superoxide) of gamma-glutamylcysteine synthetase in oviducts
7) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.59 Pain Relevance 0
One patient had a relapse of CSS within 1 week of starting montelukast and required an increase in the GCS and cyclophosphamide doses (Solans et al 2002), while the other patient did not have any increase in symptoms even after 1 year of montelukast therapy (Kalyoncu et al 2001).
Positive_regulation (increase) of GCS associated with syndrome and recurrence
8) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 1.47 Pain Relevance 0.06

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