INT100897

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.84
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCLC) small molecule metabolic process (GCLC) cellular nitrogen compound metabolic process (GCLC)
ligase activity (GCLC) cytoplasm (GCLC)
Anatomy Link Frequency
colon 2
GCLC (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 100.00 Very High Very High Very High
cINOD 34 99.84 Very High Very High Very High
Inflammation 7 91.48 High High
Inflammatory response 2 62.16 Quite High
aspirin 5 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 5 100.00 Very High Very High Very High
INFLAMMATION 19 99.12 Very High Very High Very High
Colon Cancer 46 98.00 Very High Very High Very High
Adhesions 4 88.08 High High
Cancer 9 49.20 Quite Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low
Leukemia 3 5.00 Very Low Very Low Very Low
Stomach Cancer 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that NSAIDs and resveratrol cause increases in the expression of gamma-glutamylcysteine synthetase mRNA and identify these agents as being capable of stimulating glutathione metabolism.
Positive_regulation (increases) of Gene_expression (expression) of gamma-glutamylcysteine synthetase mRNA associated with cinod
1) Confidence 0.68 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.10
Consistent with this idea, over-expression of Nrf2 increased GCLC reporter gene expression and over-expression of KIAA0132 inhibited GCLC reporter gene activity as well as inhibited indomethacin-induced increases in the expression of GCLC.
Positive_regulation (increases) of Gene_expression (expression) of GCLC
2) Confidence 0.68 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.08
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Positive_regulation (induced) of Gene_expression (expression) of gamma-glutamylcysteine synthetase
3) Confidence 0.68 Published 2002 Journal Free Radic. Biol. Med. Section Title Doc Link 11909699 Disease Relevance 0.10 Pain Relevance 0.19
Indomethacin-induced increases in the expression of gamma-glutamylcysteine synthetase mRNA were preceded by increases in steady state levels of intracellular pro-oxidants and glutathione disulfide accumulation.
Positive_regulation (increases) of Gene_expression (expression) of gamma-glutamylcysteine synthetase mRNA
4) Confidence 0.68 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.08 Pain Relevance 0.17
Exposure of HepG2 cells to nonsteroidal anti-inflammatory drugs (i.e., indomethacin and ibuprofen; NSAIDs) as well as resveratrol, caused increased expression of the mRNAs coding for the catalytic (Gclc) and modifier (Gclm) subunits of the glutathione synthetic enzyme, gamma-glutamylcysteine synthetase.
Positive_regulation (increased) of Gene_expression (expression) of gamma-glutamylcysteine synthetase associated with inflammation and cinod
5) Confidence 0.46 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.10 Pain Relevance 0.20
Exposure of HepG2 cells to nonsteroidal anti-inflammatory drugs (i.e., indomethacin and ibuprofen; NSAIDs) as well as resveratrol, caused increased expression of the mRNAs coding for the catalytic (Gclc) and modifier (Gclm) subunits of the glutathione synthetic enzyme, gamma-glutamylcysteine synthetase.
Positive_regulation (caused) of Gene_expression (expression) of gamma-glutamylcysteine synthetase associated with inflammation and cinod
6) Confidence 0.46 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.10 Pain Relevance 0.20
Expression of GCLC, involved in glutathione synthesis, was upregulated after 6 hours (Table 2).
Positive_regulation (upregulated) of Gene_expression (Expression) of GCLC
7) Confidence 0.24 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.16 Pain Relevance 0
Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.
Positive_regulation (Induction) of Gene_expression (expression) of gamma-glutamylcysteine synthetase in colon associated with inflammation, colon cancer, cinod and cox2
8) Confidence 0.24 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11820781 Disease Relevance 0.66 Pain Relevance 0.57
Expression of another oxidative stress-sensitive gene, gamma-glutamylcysteine synthetase heavy subunit gene (gamma-GCSh), which encodes the rate-limiting enzyme in glutathione biosynthesis, was also induced by sulindac.
Positive_regulation (induced) of Gene_expression (Expression) of gamma-glutamylcysteine synthetase associated with stress
9) Confidence 0.23 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11820781 Disease Relevance 0.65 Pain Relevance 0.47

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