INT100909

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.79
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2) plasma membrane (Itgb2)
Anatomy Link Frequency
astrocyte 2
Itgb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 9 99.88 Very High Very High Very High
Etanercept 6 99.04 Very High Very High Very High
Chronic pancreatitis 3 89.72 High High
COX2 1 88.48 High High
Inflammation 3 77.20 Quite High
cINOD 1 75.00 Quite High
allodynia 1 72.92 Quite High
Peripheral nerve injury 1 71.76 Quite High
Lasting pain 1 55.84 Quite High
chemokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Adhesions 4 97.12 Very High Very High Very High
Necrosis 1 90.84 High High
Cancer 1 90.48 High High
Pancreatitis 4 89.72 High High
Death 2 85.96 High High
Diabetes Mellitus 3 82.08 Quite High
Injury 2 77.60 Quite High
INFLAMMATION 4 75.00 Quite High
Diabetic Retinopathy 2 75.00 Quite High
Neuropathic Pain 1 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the expression of CD44, of the integrin component CD18, and of MHC class II was determined.
Spec (determined) Negative_regulation (determined) of Spec (determined) Gene_expression (expression) of CD18
1) Confidence 0.41 Published 2002 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 12030436 Disease Relevance 0.33 Pain Relevance 0.29
High-dose aspirin also reduced the expression of CD11a, CD11b, and CD18, whereas meloxicam and etanercept did not.
Negative_regulation (reduced) of Gene_expression (expression) of CD18 associated with aspirin and etanercept
2) Confidence 0.31 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.02 Pain Relevance 0.73
Minocycline significantly reduced microglial migration to cellular debris, astrocyte-conditioned medium, ADP, and algesic mediators and significantly reduced the expression of CD29 (beta(1)-integrin) but not CD18 (beta(2)-integrin).
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of CD18 in astrocyte
3) Confidence 0.29 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17868321 Disease Relevance 0.44 Pain Relevance 0.20

General Comments

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