INT100919

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 7.82
Pain Relevance 11.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
neurons 3
hypothalamus 2
Spinal cord 2
glial cells 1
spine 1
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 45 100.00 Very High Very High Very High
amygdala 277 99.96 Very High Very High Very High
Arthritis 145 99.84 Very High Very High Very High
nMDA receptor 95 99.80 Very High Very High Very High
Dorsal horn 47 99.76 Very High Very High Very High
Spinal cord 127 99.68 Very High Very High Very High
Pain 305 99.24 Very High Very High Very High
agonist 42 99.24 Very High Very High Very High
Kinase C 127 99.18 Very High Very High Very High
medulla 135 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 245 99.84 Very High Very High Very High
Frailty 19 99.72 Very High Very High Very High
Pain 332 99.24 Very High Very High Very High
Depression 26 94.60 High High
Hyperalgesia 2 91.36 High High
Neuropathic Pain 7 88.48 High High
Ganglion Cysts 18 87.96 High High
Nociception 80 87.60 High High
Syndrome 2 79.52 Quite High
Urological Neuroanatomy 8 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal cord injury (SCI) leads to an increase in metabotropic glutamate receptor subtype 1 (mGluR1) immunoreactivity in the peri-lesion area.
Positive_regulation (increase) of mGluR1 in Spinal cord associated with glutamate receptor, frailty and spinal cord
1) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.01 Pain Relevance 0.74
The interaction between mGluR1 and GABAergic transmission further suggests that pain-related decrease of inhibitory transmission is an active process that involves activation of mGluR1.
Positive_regulation (activation) of mGluR1 associated with pain and gabaergic
2) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.59 Pain Relevance 0.74
Therefore, activation of mGluR1 in arthritis may explain the loss of inhibitory control (disinhibition) of excitatory transmission in the CeLC.


Positive_regulation (activation) of mGluR1 associated with arthritis
3) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.72 Pain Relevance 0.64
Therefore, activation of mGluR1 that is seen in arthritis but not under normal conditions may explain the loss of inhibitory control (disinhibition) of excitatory transmission in the CeLC.
Positive_regulation (activation) of mGluR1 associated with arthritis
4) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.63 Pain Relevance 0.76
Our previous studies showed that mGluR1 and mGluR5 modulate excitatory transmission in the CeLC and upregulation of mGluR1 is associated with pain-related synaptic plasticity [20].
Positive_regulation (upregulation) of mGluR1 associated with pain
5) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.68 Pain Relevance 0.70
Results obtained with a nitric oxide (NO) donor, NO synthase inhibitors, metabotropic glutamate receptor (mGluR) agonist and mGluR1 antagonist, and a glial metabolism inhibitor suggest that after conditioning, presynaptic excitation is facilitated by NO released from glial cells via the activation of mGluR1.
Positive_regulation (activation) of mGluR1 in glial cells associated with antagonist, glutamate receptor and agonist
6) Confidence 0.64 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15525773 Disease Relevance 0.25 Pain Relevance 0.79
Spinal cord injury (SCI) leads to an increase in metabotropic glutamate receptor subtype 1 (mGluR1) immunoreactivity in the peri-lesion area.
Positive_regulation (increase) of metabotropic glutamate receptor subtype 1 in Spinal cord associated with glutamate receptor, frailty and spinal cord
7) Confidence 0.61 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.00 Pain Relevance 0.74
In the hypothalamus, metabotropic mGluR1 and mGluR3 receptors were also increased in addition to previously described findings of elevated mRNA levels in glutamatergic AMPA and NMDA subunits.
Positive_regulation (increased) of mGluR1 in hypothalamus
8) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.21 Pain Relevance 0.28
We investigated the involvement of store-operated channels (SOCs) and transient receptor potential (TRP) channels in the response to activation of the group I metabotropic glutamate receptor subtype 1 (mGluR1) with the agonist (S)-3,5-dihydroxyphenylglycine (DHPG, puff application) in dopamine neurons in rat brain slices.
Positive_regulation (activation) of metabotropic glutamate receptor subtype 1 in dopamine neurons associated with dopamine, glutamate receptor and agonist
9) Confidence 0.54 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622174 Disease Relevance 0 Pain Relevance 0.32
Our previous studies showed that in the amygdala, activation of mGluR5, but not mGluR1, enhanced the excitatory responses of CeLC neurons to innocuous and noxious stimuli in naïve animals [54,55].
Positive_regulation (activation) of mGluR1 in neurons associated with amygdala
10) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.74 Pain Relevance 0.90
The activation of group I mGluR in the spinal cord dorsal horn induced long-lasting potentiation of the polysynaptic response [18] and, to the contrary, long-lasting depression of the monosynaptic response [18,19].
Positive_regulation (activation) of group I mGluR in spinal cord dorsal horn associated with depression, dorsal horn and spinal cord
11) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.60 Pain Relevance 0.65
In the hypothalamus, the mRNA levels of GluR1, GluR3, mGluR1, mGluR3 and NR1 were significantly increased also after the administration of the highest MDMA dose, Figure 2C.
Positive_regulation (increased) of mGluR1 in hypothalamus
12) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0
Therefore, the DHPG-induced increase of sEPSC frequency, found in the present study, is probably originated from the activation of both mGluR1 and mGluR5 at terminals of other brainstem neurons or local Vo neurons, as well as the activation of mGluR5 at trigeminal afferent terminals in Vo [36].
Positive_regulation (activation) of mGluR1 in neurons associated with medulla
13) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.09 Pain Relevance 0.18
Group I mGluRs activate phospholipase C and inhibition of phospholipase C suppressed the induction but not the maintenance of epileptiform activity.
Positive_regulation (activate) of mGluRs
14) Confidence 0.33 Published 2008 Journal Epilepsy Res. Section Abstract Doc Link 18495430 Disease Relevance 0.07 Pain Relevance 0.35
Both increases in frequency and amplitude were recovered to the baseline after washout of DHPG, indicating a requirement of mGluR1 for the long-lasting increase of sEPSC amplitude.
Positive_regulation (requirement) of mGluR1
15) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.14
In summary, we provided strong evidences that the activation of group I mGluR subtypes, mGluR1 and mGluR5, and their signal transduction pathways, differentially regulates glutamate release and AMPA receptor-mediated synaptic responses in the Vo region.
Positive_regulation (activation) of group I mGluR associated with glutamate
16) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.62 Pain Relevance 0.69
In summary, we provided strong evidences that the activation of group I mGluR subtypes, mGluR1 and mGluR5, and their signal transduction pathways, differentially regulates glutamate release and AMPA receptor-mediated synaptic responses in the Vo region.
Positive_regulation (activation) of mGluR1 associated with glutamate
17) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.62 Pain Relevance 0.69
Activation of mGluR1 augments cGMP accumulation [12], which is attributable to the sequential events of nitric oxide synthase (NOS) activation, NO production and NO-sensitive guanylate cyclase (GC) activation.
Positive_regulation (Activation) of mGluR1
18) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.19
Because PKC inhibition caused enhancement of the DHPG-induced facilitation of glutamate release, it could be postulated that the activation of PKC might render feedback inhibition to the group I mGluR activation by certain mechanisms, for instance, a desensitization [17,37-39] which terminates further activation of mGluR1 and/or 5 and thereby prevents the facilitation of glutamate release.
Positive_regulation (activation) of group I mGluR associated with glutamate and kinase c
19) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.30
Because PKC inhibition caused enhancement of the DHPG-induced facilitation of glutamate release, it could be postulated that the activation of PKC might render feedback inhibition to the group I mGluR activation by certain mechanisms, for instance, a desensitization [17,37-39] which terminates further activation of mGluR1 and/or 5 and thereby prevents the facilitation of glutamate release.
Positive_regulation (activation) of mGluR1 associated with glutamate and kinase c
20) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.29

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