INT100920

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.88
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
hypothalamus 2
spinal 2
neurons 2
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 77 100.00 Very High Very High Very High
Glutamate receptor 15 100.00 Very High Very High Very High
Action potential 7 99.98 Very High Very High Very High
spinothalamic tract 12 99.84 Very High Very High Very High
Spinothalamic tract neurons 4 99.84 Very High Very High Very High
Thermal hyperalgesia 4 98.80 Very High Very High Very High
central pain 14 98.36 Very High Very High Very High
Spinal cord 18 98.32 Very High Very High Very High
Glutamate 55 98.28 Very High Very High Very High
Hippocampus 9 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Frailty 32 99.74 Very High Very High Very High
Contusions 8 99.66 Very High Very High Very High
Pain 80 99.32 Very High Very High Very High
Hyperalgesia 4 98.80 Very High Very High Very High
Syndrome 4 98.80 Very High Very High Very High
Neuropathic Pain 5 97.36 Very High Very High Very High
Arthritis 49 86.40 High High
Drug Dependence 4 56.04 Quite High
Schizophrenia 5 55.28 Quite High
Nociception 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contusion SCI produced an increase in mGluR1 expression on STT cells in both the cervical enlargement and the spinal section just rostral to contusion SCI.
Positive_regulation (increase) of Gene_expression (expression) of mGluR1 in spinal associated with spinothalamic tract, frailty and contusions
1) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.41 Pain Relevance 0.97
The increased expression of mGluR1 parallels the development of thermal hyperalgesia and mechanical allodynia and has been suggested to contribute to the development and maintenance of chronic central pain (CCP) syndromes resulting from SCI.
Positive_regulation (increased) of Gene_expression (expression) of mGluR1 associated with pain, central pain, allodynia, syndrome, thermal hyperalgesia and frailty
2) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.15 Pain Relevance 0.80
Increased expression of metabotropic glutamate receptor subtype 1 on spinothalamic tract neurons following spinal cord injury in the rat.
Positive_regulation (Increased) of Gene_expression (expression) of metabotropic glutamate receptor subtype 1 in neurons associated with pain, spinothalamic tract neurons, glutamate receptor and spinal cord
3) Confidence 0.61 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11825670 Disease Relevance 1.28 Pain Relevance 1.23
However, expression of mGluR1 has not been directly shown to increase on cells in the pain pathway.
Positive_regulation (increase) of Gene_expression (expression) of mGluR1 associated with pain
4) Confidence 0.50 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.39 Pain Relevance 0.98
Presynaptic action potential-dependent action of mGluR1 and postsynaptic action of mGluR5
Positive_regulation (dependent) of Gene_expression (action) of mGluR1 associated with action potential
5) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.54 Pain Relevance 0.42
In the hypothalamus, there was a significant increase of GluR1, GluR3, mGluR1, and mGluR3 gene-transcript expressions.


Positive_regulation (increase) of Gene_expression (expressions) of mGluR1 in hypothalamus
6) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.30
Mediation of group I mGluR subtypes in the DHPG-induced increases of sEPSC frequency and amplitude
Positive_regulation (Mediation) of Gene_expression (subtypes) of group I mGluR
7) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.16

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