INT100921

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
Spinal cord 2
basket cell 2
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 5 100.00 Very High Very High Very High
nMDA receptor 4 99.80 Very High Very High Very High
Spinal cord 2 99.72 Very High Very High Very High
tetrodotoxin 2 98.64 Very High Very High Very High
Thermal hyperalgesia 1 91.36 High High
allodynia 1 88.48 High High
central pain 3 81.04 Quite High
Calcium channel 1 78.48 Quite High
Spinothalamic tract neurons 1 75.00 Quite High
Pain 5 70.24 Quite High
Disease Link Frequency Relevance Heat
Frailty 8 99.96 Very High Very High Very High
Hyperalgesia 1 91.36 High High
Neuropathic Pain 1 88.48 High High
Pain 5 80.40 Quite High
Syndrome 1 79.52 Quite High
Contusions 2 55.68 Quite High
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal cord injury (SCI) leads to an increase in metabotropic glutamate receptor subtype 1 (mGluR1) immunoreactivity in the peri-lesion area.
Positive_regulation (leads) of Positive_regulation (increase) of mGluR1 in Spinal cord associated with glutamate receptor, frailty and spinal cord
1) Confidence 0.47 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11825670 Disease Relevance 1.01 Pain Relevance 0.74
This NO production was tetrodotoxin-sensitive, suggesting occurrence in the basket cell terminals, and required synergistic activation of mGlu-1 and NMDA receptors.
Positive_regulation (required) of Positive_regulation (activation) of mGlu-1 in basket cell associated with tetrodotoxin and nmda receptor
2) Confidence 0.06 Published 2004 Journal Neuroscience Section Abstract Doc Link 15062988 Disease Relevance 0 Pain Relevance 0.49

General Comments

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