INT100926

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.24
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
nucleus accumbens 4
forebrain 4
spinal 2
brain 2
DRG 2
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 115 100.00 Very High Very High Very High
Nucleus accumbens 52 100.00 Very High Very High Very High
ischemia 110 99.76 Very High Very High Very High
long-term potentiation 74 99.28 Very High Very High Very High
Morphine 20 98.92 Very High Very High Very High
Inflammation 13 97.48 Very High Very High Very High
Dopamine 24 95.60 Very High Very High Very High
Rostral ventromedial medulla 8 94.56 High High
nMDA receptor antagonist 4 93.84 High High
Spontaneous pain 1 93.48 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 100.00 Very High Very High Very High
Brain Hemorrhage 76 99.76 Very High Very High Very High
INFLAMMATION 12 97.48 Very High Very High Very High
Spinal Injuries 2 97.46 Very High Very High Very High
Injury 21 96.20 Very High Very High Very High
Pain 11 93.48 High High
Morphine Dependence 1 92.80 High High
Attention Deficit Hyperactivity Disorder 1 75.64 Quite High
Frailty 2 75.00 Quite High
Death 13 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis indicated that the protein translation products of the NR2A subunit were also increased (P < 0.01).
Positive_regulation (increased) of Gene_expression (products) of NR2A subunit
1) Confidence 0.63 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826044 Disease Relevance 0.86 Pain Relevance 0.94
Real-time RT-PCR showed that NR2B and NR2D were expressed at higher levels than NR2A and NR2C in DRG.
Positive_regulation (levels) of Gene_expression (expressed) of NR2A in DRG
2) Confidence 0.56 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.09 Pain Relevance 0.25
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Positive_regulation (increased) of Gene_expression (expression) of NR2A in forebrain associated with nmda receptor
3) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.29
Importantly, BD1047 (30 nmol) administered intrathecally during the induction, but not the maintenance phase, blocked the CCI-induced increase in N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation.
Positive_regulation (increase) of Gene_expression (expression) of N-methyl-D-aspartate receptor subunit 1
4) Confidence 0.50 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.05 Pain Relevance 0
Taken together with our recent molecular studies, our data are consistent with a shift away from NMDA receptor subunit (NR) NR2B and 2C function toward increased NR2A subunit expression or function after chronic morphine, a process that could alter excitability and integrative properties and may represent a neuroadaptation of NAcc medium spiny neurons underlying morphine dependence.
Positive_regulation (increased) of Gene_expression (expression) of NR2A in NAcc associated with addiction, nucleus accumbens, nmda receptor and morphine
5) Confidence 0.46 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15263066 Disease Relevance 0.09 Pain Relevance 1.24
However, the conclusion that NR2B-NMDAR is selectively involved in the induction of LTD but not LTP has been challenged by the studies using NR2A-knockout mice [12,13] and over-expression of NR2B-NMDARs [14], suggesting the existence of NR2A-independent forms of LTP.
Positive_regulation (using) of Gene_expression (expression) of NR2A-knockout associated with targeted disruption and long-term potentiation
6) Confidence 0.36 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.22 Pain Relevance 0.49
The findings showed pronounced enhancements in gene-transcript expression of GluR2, mGluR1, mGluR5, NR1, NR2A, NR2B, EAAT1, and EAAT2-2 in the cortex at bregma +1.6.
Positive_regulation (enhancements) of Gene_expression (expression) of NR2A in cortex
7) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.14 Pain Relevance 0.41
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Positive_regulation (increased) of Gene_expression (expression) of NR2A in forebrain associated with nmda receptor
8) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.30
Altered expression of NR2A and NR2B, which depends on the duration of focal cerebral ischemia, could play variable roles in secondary brain cell injury in the penumbra
Positive_regulation (depends) of Gene_expression (expression) of NR2A in brain associated with brain hemorrhage, ischemia and injury
9) Confidence 0.33 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.46 Pain Relevance 0.25
The expression of NR2A in the penumbra was significantly increased (153±9%, n=4, *P<0.05) whereas the expression of NR2B was significantly decreased (37±2%, n=4, *P<0.05) as compared with sham-operated controls 3 h after focal cerebral ischemia.
Positive_regulation (increased) of Gene_expression (expression) of NR2A associated with brain hemorrhage and ischemia
10) Confidence 0.31 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC3015038 Disease Relevance 0.50 Pain Relevance 0.40
This increase in function may be associated with an enhanced expression of NMDA receptors, particularly those in the nucleus accumbens containing the NR2A subunit.
Positive_regulation (enhanced) of Gene_expression (expression) of NR2A subunit in nucleus accumbens associated with nucleus accumbens and nmda receptor
11) Confidence 0.08 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17321516 Disease Relevance 0.14 Pain Relevance 1.41
Excitotoxic spinal injury resulted in: (1) increased phosphorylation of ERK1/2; (2) increased activation of NF-kB and phosphorylation of ELK-1; and (3) increased gene expression for the NK-1 receptor and NR1 and NR-2A subunits of the NMDA receptor.
Positive_regulation (increased) of Gene_expression (expression) of NR-2A in spinal associated with nmda receptor and spinal injuries
12) Confidence 0.05 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15922485 Disease Relevance 0.69 Pain Relevance 0.43

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