INT100939

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Context Info
Confidence 0.73
First Reported 2000
Last Reported 2011
Negated 8
Speculated 2
Reported most in Body
Documents 176
Total Number 178
Disease Relevance 125.10
Pain Relevance 43.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
lung 18
eosinophils 9
T cells 8
monocytes 4
Th2 cells 4
Il13 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3494 100.00 Very High Very High Very High
Inflammatory response 289 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
metalloproteinase 145 99.92 Very High Very High Very High
Inflammation 4537 99.82 Very High Very High Very High
Morphine 25 99.82 Very High Very High Very High
antagonist 603 99.80 Very High Very High Very High
fibrosis 1431 99.62 Very High Very High Very High
spastic colon 11 99.60 Very High Very High Very High
substance P 15 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 4667 100.00 Very High Very High Very High
INFLAMMATION 4659 100.00 Very High Very High Very High
Infection 1571 100.00 Very High Very High Very High
Targeted Disruption 361 100.00 Very High Very High Very High
Cancer 606 99.92 Very High Very High Very High
Rhinitis 453 99.88 Very High Very High Very High
Death 214 99.80 Very High Very High Very High
Necrosis 132 99.68 Very High Very High Very High
Sprains And Strains 671 99.66 Very High Very High Very High
Pulmonary Fibrosis 929 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the well-defined asthma/inflammatory genes (Il1b, Il4, Il10, Il13, Il6, Tnfa, Infg, Tgfb1) are differentially expressed, although they connect many of the genes that are.
Gene_expression (expressed) of Il13 associated with asthma and inflammation
1) Confidence 0.73 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.27 Pain Relevance 0.34
Functional studies have demonstrated a regulatory role of substituted 110Gln in addition to the involvement of Stat-6 in monocytes, decreased IL-13 receptor alpha-2 affinity for IL-13, and increased expression of IL-13 in patients with asthma,22,23 as well as AHR induction in a murine model of asthma.24 By contrast, our findings suggest that the GG genotype is associated with a risk of eosinophilic infiltration and the development of AIA.
Gene_expression (expression) of IL-13 in monocytes associated with asthma and rhinitis
2) Confidence 0.64 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.03
Cytokine changes that were apparent at the protein level [IL-4, IL-5, IL-10, IL-13, TNF-?
Gene_expression (changes) of IL-13 associated with cytokine
3) Confidence 0.64 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.15 Pain Relevance 0.05
Whilst these effects on goblet cell hyperplasia, collagen deposition and airway hyperreactivity supported the premise that H4R may modulate chronic remodeling through modulation of IL-13 production, other anti-inflammatory effects of H4R antagonism appear to be independent of the reduction in IL-13, since they were not recapitulated by anti-IL-13 treatment.
Gene_expression (production) of IL-13 in goblet cell associated with asthma, inflammation and hyperplasia
4) Confidence 0.61 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.81 Pain Relevance 0.27
Notably, a profound reduction in Th2 polarization and the production of the effector Th2 cytokine, IL-13, was observed [6].
Gene_expression (production) of IL-13 associated with cytokine
5) Confidence 0.61 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.02 Pain Relevance 0.21
agonists have been shown to reduce IL4, IL5, and IL13 production from Tcells of mice with induced lung inflammation [38,49].
Gene_expression (production) of IL13 in lung associated with inflammation, agonist and pneumonia
6) Confidence 0.61 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.46 Pain Relevance 0.36
Once adequate anesthesia was obtained, the females were given a retro-orbital injection of IL-4 or IL-13 (1000 ng, Peprotech).
Gene_expression (injection) of IL-13 associated with anesthesia
7) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.25 Pain Relevance 0.18
Absence of evidence that IL-4 or IL-13 cross the placenta
Gene_expression (cross) of IL-13 in placenta
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0
Functional studies have demonstrated a regulatory role of substituted 110Gln in addition to the involvement of Stat-6 in monocytes, decreased IL-13 receptor alpha-2 affinity for IL-13, and increased expression of IL-13 in patients with asthma,22,23 as well as AHR induction in a murine model of asthma.24 By contrast, our findings suggest that the GG genotype is associated with a risk of eosinophilic infiltration and the development of AIA.
Gene_expression (induction) of IL-13 in monocytes associated with asthma and rhinitis
9) Confidence 0.55 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.39 Pain Relevance 0.03
Association of the AIA phenotype (total eosinophil count, rhinosinusitis, FEV1, eotaxin-1) with IL-13 polymorphisms
Gene_expression (polymorphisms) of IL-13 in eosinophil associated with asthma
10) Confidence 0.55 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.34 Pain Relevance 0
In ethnic German populations, the IL-13 Arg110Gln variant has a significant association with high IgE levels.13 In addition, this allele was associated with the asthma phenotype in British and Japanese populations.14 Moreover, IL-13 is necessary and sufficient for the induction of AHR eosinophilic airway inflammation; in the absence of IL-13, this does not progress to AHR.
Neg (absence) Gene_expression (absence) of IL-13 associated with asthma, rhinitis and inflammation
11) Confidence 0.55 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.30 Pain Relevance 0.10
In ethnic German populations, the IL-13 Arg110Gln variant has a significant association with high IgE levels.13 In addition, this allele was associated with the asthma phenotype in British and Japanese populations.14 Moreover, IL-13 is necessary and sufficient for the induction of AHR eosinophilic airway inflammation; in the absence of IL-13, this does not progress to AHR.
Gene_expression (necessary) of IL-13 associated with asthma, rhinitis and inflammation
12) Confidence 0.55 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.28 Pain Relevance 0.09
Functional studies have demonstrated a regulatory role of substituted 110Gln in addition to the involvement of Stat-6 in monocytes, decreased IL-13 receptor alpha-2 affinity for IL-13, and increased expression of IL-13 in patients with asthma,22,23 as well as AHR induction in a murine model of asthma.24 By contrast, our findings suggest that the GG genotype is associated with a risk of eosinophilic infiltration and the development of AIA.
Gene_expression (expression) of IL-13 in monocytes associated with asthma and rhinitis
13) Confidence 0.55 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.03
Animals received anti-mouse IL-13 mAb once one day prior to ovalbumin challenge (i.v. 500 ?
Gene_expression (mAb) of IL-13
14) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.27 Pain Relevance 0.05
Anti-mouse IL-13 mAb (weekly i.v. 500 ?
Gene_expression (mAb) of IL-13
15) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.38 Pain Relevance 0.37
The type II receptor is made up of IL4Ra and IL-13 receptor alpha 1 (IL13Ra1) subunits.
Gene_expression (made) of IL-13
16) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.58 Pain Relevance 0.21
Similar data was seen using IL-13 injections (Figure 2, PC and NC1, NC2).
Gene_expression (injections) of IL-13
17) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0
IL-13 is a critical cytokine in the pathogenesis of allergic asthma in a mouse model of asthma,3 and is involved in several physiological changes, such as airway eosinophilia and hyper-responsiveness.4 In humans, CD4+T cells, eosinophils, mast cells, basophils, and natural killer T cells produce IL-13, inducing IgG4 and IgE synthesis in cultured B cells.5 IL-13 mRNA and protein are increased in the sputum of asthmatics and have been correlated with an increased eosinophil count6 and airway hyper-responsiveness (AHR).7 In addition, the expression of vascular cell adhesion molecule-1 (VCAM-I) is upregulated in endothelial cells, which may contribute to eosinophil migration into airway tissues.8
Gene_expression (produce) of IL-13 in B cells associated with asthma, occupational lung diseases, adhesions, eosinophilia and cytokine
18) Confidence 0.49 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.68 Pain Relevance 0.37
The increased levels of IL-13 mRNA and protein in the sputum of subjects with asthma have been correlated with an increased eosinophil count6 and airway hyper-responsiveness.7 It is generally agreed that many allergic disorders are associated with hypereosinophilia, including asthma and atopic dermatitis.
Gene_expression (levels) of IL-13 in eosinophil associated with asthma, hypersensitivity and eczema
19) Confidence 0.49 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.30 Pain Relevance 0.22
Cytokines, IL-4, IL-5 and IL-13 levels were determined in BALF, homogenized lung preparations and in PBLN culture supernatants by ELISA (R&D Systems, Minneapolis, MN).
Gene_expression (levels) of IL-13 in lung associated with cytokine
20) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.25 Pain Relevance 0.31

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