INT100940

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.59
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
hepatocytes 2
peripheral nerve 2
neutrophil 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 24 99.88 Very High Very High Very High
cINOD 4 99.84 Very High Very High Very High
Paracetamol 7 99.82 Very High Very High Very High
Pain 7 99.48 Very High Very High Very High
Inflammation 28 98.36 Very High Very High Very High
agonist 78 93.84 High High
COX-2 inhibitor 1 91.64 High High
Spinal cord 1 89.00 High High
aspirin 3 78.84 Quite High
Inflammatory response 1 71.56 Quite High
Disease Link Frequency Relevance Heat
Pain 5 99.48 Very High Very High Very High
INFLAMMATION 11 98.36 Very High Very High Very High
Schizophrenia 57 98.24 Very High Very High Very High
Targeted Disruption 12 93.72 High High
Apoptosis 1 92.68 High High
Cognitive Disorder 51 92.12 High High
Pneumonia 21 89.12 High High
Neutropenia 5 85.16 High High
Disease 62 81.28 Quite High
Hepatotoxicity 2 80.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data support a role of glial nuclear factor kappaB inhibition in reducing pain after peripheral nerve inflammation.
Regulation (role) of Negative_regulation (inhibition) of nuclear factor kappaB in peripheral nerve associated with pain and inflammation
1) Confidence 0.35 Published 2007 Journal Neuroreport Section Abstract Doc Link 17426605 Disease Relevance 0.77 Pain Relevance 0.35
In contrast, in TNFR1-/- mice, acetaminophen-induced decreases in NF-kappaB activity were prolonged and did not return to control levels for 24 h.
Regulation (prolonged) of Negative_regulation (decreases) of NF-kappaB associated with paracetamol
2) Confidence 0.32 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12842828 Disease Relevance 0.35 Pain Relevance 0.57
Effect of p50 deficiency on LPS-induced neutrophil recruitment in the absence of IL-6
Regulation (Effect) of Negative_regulation (deficiency) of p50 in neutrophil
3) Confidence 0.23 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.89 Pain Relevance 0.34
In conclusion, these data indicate that hepatocytes are not sensitive to NF-kappaB inhibition by NSAIDs and that these drugs, especially the COX-2 selective inhibitors, do not alter cell viability.
Neg (not) Regulation (sensitive) of Negative_regulation (inhibition) of NF-kappaB in hepatocytes associated with cinod
4) Confidence 0.15 Published 2002 Journal Hepatology Section Abstract Doc Link 11826407 Disease Relevance 0.44 Pain Relevance 0.56
7 nAChRs likely play an important role in the deficits of P50 auditory evoked potential in patients with schizophrenia, and that ?
Regulation (role) of Negative_regulation (deficits) of P50 associated with schizophrenia
5) Confidence 0.04 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3023065 Disease Relevance 1.13 Pain Relevance 0.08

General Comments

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