INT100941

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Context Info
Confidence 0.16
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (OAS2) mitochondrion (OAS2) endoplasmic reticulum (OAS2)
RNA binding (OAS2) nucleus (OAS2) nucleotidyltransferase activity (OAS2)
Anatomy Link Frequency
hepatocytes 2
OAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 99.52 Very High Very High Very High
cINOD 9 87.60 High High
Inflammation 7 83.36 Quite High
Infliximab 13 82.64 Quite High
Inflammatory response 1 68.96 Quite High
rheumatoid arthritis 38 66.72 Quite High
aspirin 3 62.16 Quite High
COX-2 inhibitor 1 28.40 Quite Low
COX2 1 25.00 Low Low
Sicca syndrome 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 1 99.12 Very High Very High Very High
INFLAMMATION 12 86.16 High High
Rheumatoid Arthritis 38 66.72 Quite High
Disease 15 32.96 Quite Low
Apoptosis 2 25.76 Quite Low
Syndrome 11 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 9 5.00 Very Low Very Low Very Low
Autoimmune Disease 5 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For three other IFN response genes (Mx2, OAS2, and SERPING1), a trend (P = approximately 0.06, data not shown) was observed toward increased expression in the poor responder patients.
Positive_regulation (increased) of Gene_expression (expression) of OAS2
1) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.19 Pain Relevance 0.17
Stimulation of fetal hepatocytes with proinflammatory cytokines and lipopolysaccharide promotes the expression of cyclooxygenase-2 (COX-2) and nitric oxide synthase-2 (NOS-2), whereas the hepatoma cell line HepG2 exhibits a behavior similar to that described for adult hepatocytes and only expresses NOS-2.
Positive_regulation (promotes) of Gene_expression (expression) of synthase-2 in hepatocytes associated with hepatocellular cancer and cytokine
2) Confidence 0.00 Published 2002 Journal Hepatology Section Abstract Doc Link 11826407 Disease Relevance 0.34 Pain Relevance 0.43

General Comments

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