INT100948

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Context Info
Confidence 0.12
First Reported 2001
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (NFIB) nucleus (NFIB) intracellular (NFIB)
DNA binding (NFIB)
Anatomy Link Frequency
endothelial cells 2
NFIB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 94.76 High High
aspirin 6 93.92 High High
Inflammation 2 85.88 High High
chemokine 1 76.96 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 2 99.52 Very High Very High Very High
Necrosis 2 99.28 Very High Very High Very High
Injury 2 95.04 Very High Very High Very High
INFLAMMATION 9 94.52 High High
Adhesions 2 92.24 High High
Disease 1 84.84 Quite High
Diabetes Mellitus 1 84.12 Quite High
Increased Venous Pressure Under Development 2 82.64 Quite High
Apoptosis 2 79.44 Quite High
Ulcers 2 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this assumption, as well as the possible mechanisms involved, the MCP-1 expression and secretion, the reactive oxygen species levels, nuclear factor-kB (NF-kB) and activator protein-1 (AP-1) expression were determined in human endothelial cells exposed to high glucose concentrations in the presence of aspirin, fenofibrate and clofibrate.
Spec (determined) Localization (secretion) of nuclear factor-kB in endothelial cells associated with aspirin
1) Confidence 0.12 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.51 Pain Relevance 0.34
Supporting this view, selective proteasome inhibitors inhibit nuclear translocation of nuclear factor-kB induced by tumor necrosis factor-alpha in human endothelial cells in vitro and reduce indomethacin-induced gastric mucosal injury in vivo.
Localization (translocation) of nuclear factor-kB in endothelial cells associated with necrosis, cancer and injury
2) Confidence 0.02 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827361 Disease Relevance 1.30 Pain Relevance 0.29

General Comments

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